CPA2 (carboxypeptidase A2)

2014-11-01  

Identity

HGNC
CPA2
LOCATION
7q32.2
LOCUSID
1358
ALIAS
-

Other Information

Locus ID:

NCBI: 1358
MIM: 600688
HGNC: 2297
Ensembl: ENSG00000158516

Variants:

dbSNP: 1358
ClinVar: 1358
TCGA: ENSG00000158516
COSMIC: CPA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158516ENST00000222481P48052
ENSG00000158516ENST00000416698J3QT58

Expression (GTEx)

0
5000
10000
15000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA445220PancreatitisDiseaseClinicalAnnotationassociatedPD27114598
PA446155Precursor Cell Lymphoblastic Leukemia-LymphomaDiseaseClinicalAnnotationassociatedPD27114598
PA448492asparaginaseChemicalClinicalAnnotationassociatedPD27114598

References

Pubmed IDYearTitleCitations
273584032016Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2.18
273584032016Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2.18
261150972015Probing the Residual Structure of the Low Populated Denatured State of ADA2h under Folding Conditions by Relaxation Dispersion Nuclear Magnetic Resonance Spectroscopy.2
263165922015Variants in pancreatic carboxypeptidase genes CPA2 and CPB1 are not associated with chronic pancreatitis.9
261150972015Probing the Residual Structure of the Low Populated Denatured State of ADA2h under Folding Conditions by Relaxation Dispersion Nuclear Magnetic Resonance Spectroscopy.2
263165922015Variants in pancreatic carboxypeptidase genes CPA2 and CPB1 are not associated with chronic pancreatitis.9
210980232011Chymotrypsin C is a co-activator of human pancreatic procarboxypeptidases A1 and A2.21
210980232011Chymotrypsin C is a co-activator of human pancreatic procarboxypeptidases A1 and A2.21
194016822010High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility.71
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
194016822010High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility.71
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
198175002009Influence of aggregation propensity and stability on amyloid fibril formation as studied by Fourier transform infrared spectroscopy and two-dimensional COS analysis.4
198175002009Influence of aggregation propensity and stability on amyloid fibril formation as studied by Fourier transform infrared spectroscopy and two-dimensional COS analysis.4
171969782007High-resolution structural and thermodynamic analysis of extreme stabilization of human procarboxypeptidase by computational protein design.46

Citation

Dessen P

CPA2 (carboxypeptidase A2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62044/cpa2-(carboxypeptidase-a2)