Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1358
MIM: 600688
HGNC: 2297
Ensembl: ENSG00000158516
Variants:
dbSNP: 1358
ClinVar: 1358
TCGA: ENSG00000158516
COSMIC: CPA2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000158516 | ENST00000222481 | P48052 |
| ENSG00000158516 | ENST00000416698 | J3QT58 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Pancreatic secretion | KEGG | ko04972 |
| Pancreatic secretion | KEGG | hsa04972 |
| Protein digestion and absorption | KEGG | ko04974 |
| Protein digestion and absorption | KEGG | hsa04974 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA445220 | Pancreatitis | Disease | ClinicalAnnotation | associated | PD | 27114598 | |
| PA446155 | Precursor Cell Lymphoblastic Leukemia-Lymphoma | Disease | ClinicalAnnotation | associated | PD | 27114598 | |
| PA448492 | asparaginase | Chemical | ClinicalAnnotation | associated | PD | 27114598 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 27358403 | 2016 | Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2. | 18 |
| 27358403 | 2016 | Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2. | 18 |
| 26115097 | 2015 | Probing the Residual Structure of the Low Populated Denatured State of ADA2h under Folding Conditions by Relaxation Dispersion Nuclear Magnetic Resonance Spectroscopy. | 2 |
| 26316592 | 2015 | Variants in pancreatic carboxypeptidase genes CPA2 and CPB1 are not associated with chronic pancreatitis. | 9 |
| 26115097 | 2015 | Probing the Residual Structure of the Low Populated Denatured State of ADA2h under Folding Conditions by Relaxation Dispersion Nuclear Magnetic Resonance Spectroscopy. | 2 |
| 26316592 | 2015 | Variants in pancreatic carboxypeptidase genes CPA2 and CPB1 are not associated with chronic pancreatitis. | 9 |
| 21098023 | 2011 | Chymotrypsin C is a co-activator of human pancreatic procarboxypeptidases A1 and A2. | 21 |
| 21098023 | 2011 | Chymotrypsin C is a co-activator of human pancreatic procarboxypeptidases A1 and A2. | 21 |
| 19401682 | 2010 | High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. | 71 |
| 20379614 | 2010 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | 78 |
| 19401682 | 2010 | High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. | 71 |
| 20379614 | 2010 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | 78 |
| 19817500 | 2009 | Influence of aggregation propensity and stability on amyloid fibril formation as studied by Fourier transform infrared spectroscopy and two-dimensional COS analysis. | 4 |
| 19817500 | 2009 | Influence of aggregation propensity and stability on amyloid fibril formation as studied by Fourier transform infrared spectroscopy and two-dimensional COS analysis. | 4 |
| 17196978 | 2007 | High-resolution structural and thermodynamic analysis of extreme stabilization of human procarboxypeptidase by computational protein design. | 46 |
Citation
Dessen P
CPA2 (carboxypeptidase A2)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/62044/cpa2-(carboxypeptidase-a2)
