Identity
HGNC
LOCATION
16q24.1
LOCUSID
ALIAS
CRISP11,LCRISP2,LGL1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 83716
MIM: 612434
HGNC: 25248
Ensembl: ENSG00000103196
Variants:
dbSNP: 83716
ClinVar: 83716
TCGA: ENSG00000103196
COSMIC: CRISPLD2
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Immune System | REACTOME | R-HSA-168256 |
| Innate Immune System | REACTOME | R-HSA-168249 |
| Neutrophil degranulation | REACTOME | R-HSA-6798695 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA198 | IL6 | Gene | Literature, MultilinkAnnotation | associated | 24926665 | ||
| PA29841 | CXCL8 | Gene | Literature, MultilinkAnnotation | associated | 24926665 | ||
| PA449247 | dexamethasone | Chemical | Literature, MultilinkAnnotation | associated | 24926665 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37021796 | 2023 | Decreased CRISPLD2 expression impairs osteogenic differentiation of human mesenchymal stem cells during in vitro expansion. | 1 |
| 37021796 | 2023 | Decreased CRISPLD2 expression impairs osteogenic differentiation of human mesenchymal stem cells during in vitro expansion. | 1 |
| 34624316 | 2021 | Identification of Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma. | 0 |
| 34624316 | 2021 | Identification of Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma. | 0 |
| 31557467 | 2019 | Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma. | 4 |
| 31557467 | 2019 | Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma. | 4 |
| 29437515 | 2018 | Association Between CRISPLD2 Polymorphisms and the Risk of Nonsyndromic Clefts of the Lip and/or Palate: A Meta-analysis. | 6 |
| 29899370 | 2018 | Knockdown of Crispld2 in zebrafish identifies a novel network for nonsyndromic cleft lip with or without cleft palate candidate genes. | 10 |
| 29437515 | 2018 | Association Between CRISPLD2 Polymorphisms and the Risk of Nonsyndromic Clefts of the Lip and/or Palate: A Meta-analysis. | 6 |
| 29899370 | 2018 | Knockdown of Crispld2 in zebrafish identifies a novel network for nonsyndromic cleft lip with or without cleft palate candidate genes. | 10 |
| 27328068 | 2017 | Brazilian multicenter study of association between polymorphisms in CRISPLD2 and JARID2 and non-syndromic oral clefts. | 6 |
| 27328068 | 2017 | Brazilian multicenter study of association between polymorphisms in CRISPLD2 and JARID2 and non-syndromic oral clefts. | 6 |
| 26624800 | 2016 | HMGB1 induced inflammatory effect is blocked by CRISPLD2 via MiR155 in hepatic fibrogenesis. | 6 |
| 27597766 | 2016 | CRISPLD2 (LGL1) inhibits proinflammatory mediators in human fetal, adult, and COPD lung fibroblasts and epithelial cells. | 19 |
| 26624800 | 2016 | HMGB1 induced inflammatory effect is blocked by CRISPLD2 via MiR155 in hepatic fibrogenesis. | 6 |
Citation
Dessen P
CRISPLD2 (cysteine rich secretory protein LCCL domain containing 2)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/62091/crispld2-(cysteine-rich-secretory-protein-lccl-domain-containing-2)
