CRISPLD2 (cysteine rich secretory protein LCCL domain containing 2)

2014-11-01 Affiliation

Identity

HGNC

CRISPLD2

LOCATION

16q24.1

LOCUSID

83716

ALIAS

CRISP11,LCRISP2,LGL1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 83716
MIM: 612434
HGNC: 25248
Ensembl: ENSG00000103196

Variants:

dbSNP: 83716
ClinVar: 83716
TCGA: ENSG00000103196
COSMIC: CRISPLD2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000103196	ENST00000262424	Q9H0B8
ENSG00000103196	ENST00000262424	A0A140VK80
ENSG00000103196	ENST00000563066	H3BSZ9
ENSG00000103196	ENST00000564567	Q9H0B8
ENSG00000103196	ENST00000566151	H3BS62
ENSG00000103196	ENST00000566165	J3QKP2
ENSG00000103196	ENST00000566789	H3BTP0
ENSG00000103196	ENST00000567845	H3BTI0
ENSG00000103196	ENST00000569090	Q9H0B8

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Neutrophil degranulation	REACTOME	R-HSA-6798695

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA198	IL6	Gene	Literature, MultilinkAnnotation	associated	24926665
PA29841	CXCL8	Gene	Literature, MultilinkAnnotation	associated	24926665
PA449247	dexamethasone	Chemical	Literature, MultilinkAnnotation	associated	24926665

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
17616516	2007	CRISPLD2: a novel NSCLP candidate gene.	37
17616516	2007	CRISPLD2: a novel NSCLP candidate gene.	37
19864597	2009	The novel lipopolysaccharide-binding protein CRISPLD2 is a critical serum protein to regulate endotoxin function.	22
19937600	2010	Testing reported associations of genetic risk factors for oral clefts in a large Irish study population.	18
24955763	2014	CRISPLD2 is a target of progesterone receptor and its expression is decreased in women with endometriosis.	12
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	11
27597766	2016	CRISPLD2 (LGL1) inhibits proinflammatory mediators in human fetal, adult, and COPD lung fibroblasts and epithelial cells.	11
24090571	2014	Both LCCL-domains of human CRISPLD2 have high affinity for lipid A.	9
25480331	2015	LGL1 modulates proliferation, apoptosis, and migration of human fetal lung fibroblasts.	9

Citation

Dessen P

CRISPLD2 (cysteine rich secretory protein LCCL domain containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62091/crispld2-(cysteine-rich-secretory-protein-lccl-domain-containing-2)