ALOX5AP (arachidonate 5-lipoxygenase activating protein)

2003-06-01  

Identity

HGNC
LOCATION
13q12.3
LOCUSID
ALIAS
FLAP
FUSION GENES

Other Information

Locus ID:

NCBI: 241
MIM: 603700
HGNC: 436
Ensembl: ENSG00000132965

Variants:

dbSNP: 241
ClinVar: 241
TCGA: ENSG00000132965
COSMIC: ALOX5AP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132965ENST00000380490P20292
ENSG00000132965ENST00000617770A0A087WW23

Expression (GTEx)

0
100
200
300
400
500
600
700

Pathways

PathwaySourceExternal ID
Fc epsilon RI signaling pathwayKEGGko04664
Fc epsilon RI signaling pathwayKEGGhsa04664
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of Leukotrienes (LT) and Eoxins (EX)REACTOMER-HSA-2142691
Synthesis of 5-eicosatetraenoic acidsREACTOMER-HSA-2142688
Synthesis of Lipoxins (LX)REACTOMER-HSA-2142700

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
147701842004The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke.183
147701842004The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke.183
147024252004Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis.127
162829742006A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction.82
176001842007Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein.63
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
156409732005Association between the gene encoding 5-lipoxygenase-activating protein and stroke replicated in a Scottish population.61
156409732005Association between the gene encoding 5-lipoxygenase-activating protein and stroke replicated in a Scottish population.61
158610052005Molecular genetics of coronary artery disease.45
157314792005ALOX5AP gene and the PDE4D gene in a central European population of stroke patients.43

Citation

Dessen P

ALOX5AP (arachidonate 5-lipoxygenase activating protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/621/alox5ap-(arachidonate-5-lipoxygenase-activating-protein)