CSN2 (casein beta)

2014-11-01 Affiliation

Identity

HGNC

CSN2

LOCATION

4q13.3

LOCUSID

1447

ALIAS

CASB,PDC213

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1447
MIM: 115460
HGNC: 2447
Ensembl: ENSG00000135222

Variants:

dbSNP: 1447
ClinVar: 1447
TCGA: ENSG00000135222
COSMIC: CSN2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000135222	ENST00000353151	P05814
ENSG00000135222	ENST00000353151	W5RWE1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Prolactin signaling pathway	KEGG	hsa04917
Prolactin signaling pathway	KEGG	ko04917
Signal Transduction	REACTOME	R-HSA-162582
Signaling by ERBB4	REACTOME	R-HSA-1236394
Nuclear signaling by ERBB4	REACTOME	R-HSA-1251985

Protein levels (Protein atlas)

Not detected

Low

Medium

High

cerebral cortex

cerebellum

hippocampus

caudate

thyroid gland

parathyroid gland

adrenal gland

nasopharynx

bronchus

lung

oral mucosa

salivary gland

esophagus

stomach 1

stomach 2

duodenum

small intestine

colon

rectum

liver

gallbladder

pancreas

kidney

urinary bladder

testis

epididymis

seminal vesicle

prostate

vagina

ovary

fallopian tube

endometrium 1

endometrium 2

cervix, uterine

placenta

breast

lactating breast

heart muscle

smooth muscle

skeletal muscle

soft tissue 1

soft tissue 2

adipose tissue

skin 1

skin 2

appendix

spleen

lymph node

tonsil

bone marrow

References

Pubmed ID	Year	Title	Citations
28093229	2017	Antimicrobial activity and mechanism of PDC213, an endogenous peptide from human milk.	4
28093229	2017	Antimicrobial activity and mechanism of PDC213, an endogenous peptide from human milk.	4
27611101	2016	Differential neurogenic effects of casein-derived opioid peptides on neuronal stem cells: implications for redox-based epigenetic changes.	11
27611101	2016	Differential neurogenic effects of casein-derived opioid peptides on neuronal stem cells: implications for redox-based epigenetic changes.	11
24189037	2014	Enhanced levels of immunoreactive β-casomorphin-8 in milk of breastfeeding women with mastitis.	2
24364857	2014	The role of anionic peptide fragments in 1N4R human tau protein aggregation.	5
25087955	2014	Serotonin suppresses β-casein expression via inhibition of the signal transducer and activator of transcription 5 (STAT5) protein phosphorylation in human mammary epithelial cells MCF-12A.	9
24189037	2014	Enhanced levels of immunoreactive β-casomorphin-8 in milk of breastfeeding women with mastitis.	2
24364857	2014	The role of anionic peptide fragments in 1N4R human tau protein aggregation.	5
25087955	2014	Serotonin suppresses β-casein expression via inhibition of the signal transducer and activator of transcription 5 (STAT5) protein phosphorylation in human mammary epithelial cells MCF-12A.	9
19463972	2009	Derivatives of human beta-casein fragments (54-59) exhibit highly potent immunosuppressant activity.	0
19463972	2009	Derivatives of human beta-casein fragments (54-59) exhibit highly potent immunosuppressant activity.	0
16973758	2007	Progesterone receptor repression of prolactin/signal transducer and activator of transcription 5-mediated transcription of the beta-casein gene in mammary epithelial cells.	28
16973758	2007	Progesterone receptor repression of prolactin/signal transducer and activator of transcription 5-mediated transcription of the beta-casein gene in mammary epithelial cells.	28
16947075	2006	Reconstituted micelle formation using reduced, carboxymethylated bovine kappa-casein and human beta-casein.	0

Citation

Dessen P

CSN2 (casein beta)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62129/csn2-(casein-beta)