CTDNEP1 (CTD nuclear envelope phosphatase 1)

2014-11-01  

Identity

HGNC
CTDNEP1
LOCATION
17p13.1
LOCUSID
23399
ALIAS
DULLARD,HSA011916,NET56
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23399
MIM: 610684
HGNC: 19085
Ensembl: ENSG00000175826

Variants:

dbSNP: 23399
ClinVar: 23399
TCGA: ENSG00000175826
COSMIC: CTDNEP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175826ENST00000318988O95476
ENSG00000175826ENST00000570380I3L4W0
ENSG00000175826ENST00000570828I3L3K5
ENSG00000175826ENST00000571409I3L0X6
ENSG00000175826ENST00000572043I3L2R5
ENSG00000175826ENST00000573600O95476
ENSG00000175826ENST00000574205O95476
ENSG00000175826ENST00000574322O95476
ENSG00000175826ENST00000575783I3L4B2
ENSG00000175826ENST00000576613I3L1D9

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic ProphaseREACTOMER-HSA-68875
Nuclear Envelope BreakdownREACTOMER-HSA-2980766
Depolymerisation of the Nuclear LaminaREACTOMER-HSA-4419969

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
387763702024Structure and mechanism of the human CTDNEP1-NEP1R1 membrane protein phosphatase complex necessary to maintain ER membrane morphology.1
387763702024Structure and mechanism of the human CTDNEP1-NEP1R1 membrane protein phosphatase complex necessary to maintain ER membrane morphology.1
367650892023Loss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma by triggering MYC amplification and genomic instability.7
367650892023Loss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma by triggering MYC amplification and genomic instability.7
322718602020Regulated lipid synthesis and LEM2/CHMP7 jointly control nuclear envelope closure.35
322718602020Regulated lipid synthesis and LEM2/CHMP7 jointly control nuclear envelope closure.35
282878112017Two Triacylglycerol Pathway Genes, CTDNEP1 and LPIN1, are Down-Regulated by hsa-miR-122-5p in Hepatocytes.11
282878112017Two Triacylglycerol Pathway Genes, CTDNEP1 and LPIN1, are Down-Regulated by hsa-miR-122-5p in Hepatocytes.11
214137882011Homo sapiens dullard protein phosphatase shows a preference for the insulin-dependent phosphorylation site of lipin1.16
214137882011Homo sapiens dullard protein phosphatase shows a preference for the insulin-dependent phosphorylation site of lipin1.16
174204452007A conserved phosphatase cascade that regulates nuclear membrane biogenesis.95
174204452007A conserved phosphatase cascade that regulates nuclear membrane biogenesis.95

Citation

Dessen P

CTDNEP1 (CTD nuclear envelope phosphatase 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62178