CTRB1 (chymotrypsinogen B1)

2014-11-01 Affiliation

Identity

HGNC

CTRB1

LOCATION

16q23.1

LOCUSID

1504

ALIAS

CTRB

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1504
MIM: 118890
HGNC: 2521
Ensembl: ENSG00000168925

Variants:

dbSNP: 1504
ClinVar: 1504
TCGA: ENSG00000168925
COSMIC: CTRB1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000168925	ENST00000361017	P17538
ENSG00000168925	ENST00000495583	J3QKZ2
ENSG00000168925	ENST00000642378	A0A2R8Y4E9

Expression (GTEx)

5000

10000

15000

20000

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Pancreatic secretion	KEGG	ko04972
Pancreatic secretion	KEGG	hsa04972
Protein digestion and absorption	KEGG	ko04974
Protein digestion and absorption	KEGG	hsa04974
Metabolism	REACTOME	R-HSA-1430728
Metabolism of vitamins and cofactors	REACTOME	R-HSA-196854
Metabolism of water-soluble vitamins and cofactors	REACTOME	R-HSA-196849
Cobalamin (Cbl, vitamin B12) transport and metabolism	REACTOME	R-HSA-196741
Extracellular matrix organization	REACTOME	R-HSA-1474244
Degradation of the extracellular matrix	REACTOME	R-HSA-1474228
Activation of Matrix Metalloproteinases	REACTOME	R-HSA-1592389

References

Pubmed ID	Year	Title	Citations
33036922	2020	Sequencing of the complex CTRB1-CTRB2 locus in chronic pancreatitis.	2
33036922	2020	Sequencing of the complex CTRB1-CTRB2 locus in chronic pancreatitis.	2
28754779	2018	Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.	46
28754779	2018	Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.	46
28011711	2016	Protective coding variants in CFH and PELI3 and a variant near CTRB1 are associated with age-related macular degeneration†.	11
28011711	2016	Protective coding variants in CFH and PELI3 and a variant near CTRB1 are associated with age-related macular degeneration†.	11
19844255	2010	Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects.	10
19844255	2010	Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects.	10

Citation

Dessen P

CTRB1 (chymotrypsinogen B1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62187/teaching-explorer/favicon/welcome