CTRB2 (chymotrypsinogen B2)

2014-11-01  

Identity

HGNC
LOCATION
16q23.1
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 440387
HGNC: 2522
Ensembl: ENSG00000168928

Variants:

dbSNP: 440387
ClinVar: 440387
TCGA: ENSG00000168928
COSMIC: CTRB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168928ENST00000303037Q6GPI1
ENSG00000168928ENST00000562106H3BMY1
ENSG00000168928ENST00000562387H3BP92
ENSG00000168928ENST00000567767H3BTQ4

Expression (GTEx)

0
5000
10000
15000
20000

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Cobalamin (Cbl, vitamin B12) transport and metabolismREACTOMER-HSA-196741
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Activation of Matrix MetalloproteinasesREACTOMER-HSA-1592389

References

Pubmed IDYearTitleCitations
359342982022Arg236 in human chymotrypsin B2 (CTRB2) is a key determinant of high enzyme activity, trypsinogen degradation capacity, and protection against pancreatitis.5
359342982022Arg236 in human chymotrypsin B2 (CTRB2) is a key determinant of high enzyme activity, trypsinogen degradation capacity, and protection against pancreatitis.5
345599952021A 584 bp deletion in CTRB2 inhibits chymotrypsin B2 activity and secretion and confers risk of pancreatic cancer.12
345599952021A 584 bp deletion in CTRB2 inhibits chymotrypsin B2 activity and secretion and confers risk of pancreatic cancer.12
330369222020Sequencing of the complex CTRB1-CTRB2 locus in chronic pancreatitis.2
330369222020Sequencing of the complex CTRB1-CTRB2 locus in chronic pancreatitis.2
287547792018Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.46
287547792018Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.46

Citation

Dessen P

CTRB2 (chymotrypsinogen B2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62188/ctrb2-(chymotrypsinogen-b2)