CTU2 (cytosolic thiouridylase subunit 2)

2014-11-01  

Identity

HGNC
CTU2
LOCATION
16q24.3
LOCUSID
348180
ALIAS
C16orf84,MFRG,NCS2,UPF0432
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 348180
MIM: 617057
HGNC: 28005
Ensembl: ENSG00000174177

Variants:

dbSNP: 348180
ClinVar: 348180
TCGA: ENSG00000174177
COSMIC: CTU2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174177ENST00000312060Q2VPK5
ENSG00000174177ENST00000453996Q2VPK5
ENSG00000174177ENST00000564105H3BNM3
ENSG00000174177ENST00000564921H3BNU5
ENSG00000174177ENST00000567316H3BPG4
ENSG00000174177ENST00000567949H3BSW6

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Sulfur relay systemKEGGko04122
Sulfur relay systemKEGGhsa04122
Gene ExpressionREACTOMER-HSA-74160
tRNA processingREACTOMER-HSA-72306
tRNA modification in the nucleus and cytosolREACTOMER-HSA-6782315

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
386303552024Activation of CTU2 expression by LXR promotes the development of hepatocellular carcinoma.0
386303552024Activation of CTU2 expression by LXR promotes the development of hepatocellular carcinoma.0
313011552019Biallelic variants in CTU2 cause DREAM-PL syndrome and impair thiolation of tRNA wobble U34.11
313011552019Biallelic variants in CTU2 cause DREAM-PL syndrome and impair thiolation of tRNA wobble U34.11
190178112008A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway.70
190178112008A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway.70

Citation

Dessen P

CTU2 (cytosolic thiouridylase subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62198/ctu2-(cytosolic-thiouridylase-subunit-2)