ALPI (alkaline phosphatase, intestinal)

2003-11-01  

Identity

HGNC
ALPI
LOCATION
2q37.1
LOCUSID
248
ALIAS
IAP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 248
MIM: 171740
HGNC: 437
Ensembl: ENSG00000163295

Variants:

dbSNP: 248
ClinVar: 248
TCGA: ENSG00000163295
COSMIC: ALPI

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163295ENST00000295463P09923
ENSG00000163295ENST00000295463A0A024R4A2
ENSG00000163295ENST00000457560F8WEQ0

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Thiamine metabolismKEGGko00730
Folate biosynthesisKEGGko00790
Thiamine metabolismKEGGhsa00730
Folate biosynthesisKEGGhsa00790
Metabolic pathwaysKEGGhsa01100
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Post-translational modification: synthesis of GPI-anchored proteinsREACTOMER-HSA-163125
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Synthesis of PAREACTOMER-HSA-1483166
Miscellaneous digestion eventsREACTOMER-HSA-8935690

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378702352024Effect of Surgery on Postoperative Levels of the Gut Homeostasis-Regulating Enzyme Intestinal Alkaline Phosphatase.1
378702352024Effect of Surgery on Postoperative Levels of the Gut Homeostasis-Regulating Enzyme Intestinal Alkaline Phosphatase.1
373009912023The role of intestinal alkaline phosphatase in the development of necrotizing enterocolitis.1
373009912023The role of intestinal alkaline phosphatase in the development of necrotizing enterocolitis.1
350821352022Intestinal alkaline phosphatase deficiency increases the risk of diabetes.4
356945412022Intestinal Alkaline Phosphatase Prevents Sulfate Reducing Bacteria-Induced Increased Tight Junction Permeability by Inhibiting Snail Pathway.6
360471002022Characterization and Structure of Alternatively Spliced Transcript Variant of Human Intestinal Alkaline Phosphatase (ALPI) Gene.1
350821352022Intestinal alkaline phosphatase deficiency increases the risk of diabetes.4
356945412022Intestinal Alkaline Phosphatase Prevents Sulfate Reducing Bacteria-Induced Increased Tight Junction Permeability by Inhibiting Snail Pathway.6
360471002022Characterization and Structure of Alternatively Spliced Transcript Variant of Human Intestinal Alkaline Phosphatase (ALPI) Gene.1
333914582021A role for intestinal alkaline phosphatase in preventing liver fibrosis.20
349444282021Role of Intestinal Alkaline Phosphatase in Innate Immunity.15
333914582021A role for intestinal alkaline phosphatase in preventing liver fibrosis.20
349444282021Role of Intestinal Alkaline Phosphatase in Innate Immunity.15
319154702019Intestinal Alkaline Phosphatase Deficiency Is Associated with Ischemic Heart Disease.5

Citation

Dessen P

ALPI (alkaline phosphatase, intestinal)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/622/alpi-(alkaline-phosphatase-intestinal)