Identity
HGNC
LOCATION
6q14.2
LOCUSID
ALIAS
NCB5OR,cb5/cb5R,dJ676J13.1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 51167
MIM: 608343
HGNC: 20147
Ensembl: ENSG00000065615
Variants:
dbSNP: 51167
ClinVar: 51167
TCGA: ENSG00000065615
COSMIC: CYB5R4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000065615 | ENST00000369679 | A0A0A0MRM6 |
| ENSG00000065615 | ENST00000369681 | Q7L1T6 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10176 | rasburicase | Chemical | LabelAnnotation | associated | |||
| PA450125 | isosorbide dinitrate | Chemical | LabelAnnotation | associated | |||
| PA450126 | isosorbide mononitrate | Chemical | LabelAnnotation | associated | |||
| PA450475 | metoclopramide | Chemical | LabelAnnotation | associated | |||
| PA451103 | primaquine | Chemical | LabelAnnotation | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38041394 | 2024 | The N-terminal intrinsically disordered region of Ncb5or docks with the cytochrome b(5) core to form a helical motif that is of ancient origin. | 0 |
| 38041394 | 2024 | The N-terminal intrinsically disordered region of Ncb5or docks with the cytochrome b(5) core to form a helical motif that is of ancient origin. | 0 |
| 26878259 | 2016 | Cytosolic localization of NADH cytochrome b₅ oxidoreductase (Ncb5or). | 1 |
| 26878259 | 2016 | Cytosolic localization of NADH cytochrome b₅ oxidoreductase (Ncb5or). | 1 |
| 23523930 | 2013 | Natural mutations lead to enhanced proteasomal degradation of human Ncb5or, a novel flavoheme reductase. | 7 |
| 23523930 | 2013 | Natural mutations lead to enhanced proteasomal degradation of human Ncb5or, a novel flavoheme reductase. | 7 |
| 22627575 | 2012 | Methemoglobin reductase deficiency: novel mutation is associated with a disease phenotype of intermediate severity. | 6 |
| 22627575 | 2012 | Methemoglobin reductase deficiency: novel mutation is associated with a disease phenotype of intermediate severity. | 6 |
| 20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. | 15 |
| 20630863 | 2010 | Study of the individual cytochrome b5 and cytochrome b5 reductase domains of Ncb5or reveals a unique heme pocket and a possible role of the CS domain. | 13 |
| 20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. | 15 |
| 20630863 | 2010 | Study of the individual cytochrome b5 and cytochrome b5 reductase domains of Ncb5or reveals a unique heme pocket and a possible role of the CS domain. | 13 |
| 19913121 | 2009 | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. | 105 |
| 19913121 | 2009 | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. | 105 |
| 15131110 | 2004 | NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum. | 24 |
Citation
Dessen P
CYB5R4 (cytochrome b5 reductase 4)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/62237/cyb5r4-(cytochrome-b5-reductase-4)
