CYP4F11 (cytochrome P450 family 4 subfamily F member 11)

2014-11-01  

Identity

HGNC
CYP4F11
LOCATION
19p13.12
LOCUSID
57834
ALIAS
CYPIVF11
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57834
MIM: 611517
HGNC: 13265
Ensembl: ENSG00000171903

Variants:

dbSNP: 57834
ClinVar: 57834
TCGA: ENSG00000171903
COSMIC: CYP4F11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171903ENST00000248041Q9HBI6
ENSG00000171903ENST00000326742F8W978
ENSG00000171903ENST00000402119Q9HBI6
ENSG00000171903ENST00000591841V9GYP6
ENSG00000171903ENST00000620614F8W978

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of Leukotrienes (LT) and Eoxins (EX)REACTOMER-HSA-2142691
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cytochrome P450 - arranged by substrate typeREACTOMER-HSA-211897
Fatty acidsREACTOMER-HSA-211935
EicosanoidsREACTOMER-HSA-211979
Miscellaneous substratesREACTOMER-HSA-211958

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA451906warfarinChemicalClinicalAnnotationassociatedPD28620303

References

Pubmed IDYearTitleCitations
379733742024Deciphering the Role of Fatty Acid-Metabolizing CYP4F11 in Lung Cancer and Its Potential As a Drug Target.0
379733742024Deciphering the Role of Fatty Acid-Metabolizing CYP4F11 in Lung Cancer and Its Potential As a Drug Target.0
333106632021Regulation of cytochrome P450 4F11 expression by liver X receptor alpha.0
340594462021A novel gene associated with small bowel bleeding in patients taking low-dose aspirin.2
333106632021Regulation of cytochrome P450 4F11 expression by liver X receptor alpha.0
340594462021A novel gene associated with small bowel bleeding in patients taking low-dose aspirin.2
283476612017Functional characterization of a common CYP4F11 genetic variant and identification of functionally defective CYP4F11 variants in erythromycin metabolism and 20-HETE synthesis.6
283476612017Functional characterization of a common CYP4F11 genetic variant and identification of functionally defective CYP4F11 variants in erythromycin metabolism and 20-HETE synthesis.6
241385312013Cytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11.38
241385312013Cytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11.38
198123492010Gene regulation of CYP4F11 in human keratinocyte HaCaT cells.10
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
206898072010Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer.27
198123492010Gene regulation of CYP4F11 in human keratinocyte HaCaT cells.10
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78

Citation

Dessen P

CYP4F11 (cytochrome P450 family 4 subfamily F member 11)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62259/cyp4f11-(cytochrome-p450-family-4-subfamily-f-member-11)