Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1595
MIM: 601637
HGNC: 2649
Ensembl: ENSG00000001630
Variants:
dbSNP: 1595
ClinVar: 1595
TCGA: ENSG00000001630
COSMIC: CYP51A1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000001630 | ENST00000003100 | A0A0C4DFL7 |
| ENSG00000001630 | ENST00000422867 | H7C0D0 |
| ENSG00000001630 | ENST00000450723 | Q16850 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38272204 | 2024 | The effect of membrane composition on the interaction between human CYP51 and its flavonoid inhibitor - luteolin 7,3'-disulfate. | 1 |
| 38272204 | 2024 | The effect of membrane composition on the interaction between human CYP51 and its flavonoid inhibitor - luteolin 7,3'-disulfate. | 1 |
| 36413274 | 2023 | CYP51-mediated cholesterol biosynthesis is required for the proliferation of CD4(+) T cells in Sjogren's syndrome. | 3 |
| 36870163 | 2023 | Revealing substrate-induced structural changes in active site of human CYP51 in the presence of its physiological substrates. | 0 |
| 37209823 | 2023 | Processive kinetics in the three-step lanosterol 14α-demethylation reaction catalyzed by human cytochrome P450 51A1. | 4 |
| 36413274 | 2023 | CYP51-mediated cholesterol biosynthesis is required for the proliferation of CD4(+) T cells in Sjogren's syndrome. | 3 |
| 36870163 | 2023 | Revealing substrate-induced structural changes in active site of human CYP51 in the presence of its physiological substrates. | 0 |
| 37209823 | 2023 | Processive kinetics in the three-step lanosterol 14α-demethylation reaction catalyzed by human cytochrome P450 51A1. | 4 |
| 33031537 | 2021 | Concerning P450 Evolution: Structural Analyses Support Bacterial Origin of Sterol 14α-Demethylases. | 15 |
| 33031537 | 2021 | Concerning P450 Evolution: Structural Analyses Support Bacterial Origin of Sterol 14α-Demethylases. | 15 |
| 31904814 | 2020 | The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6. | 11 |
| 32493730 | 2020 | A requirement for an active proton delivery network supports a compound I-mediated C-C bond cleavage in CYP51 catalysis. | 14 |
| 31904814 | 2020 | The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6. | 11 |
| 32493730 | 2020 | A requirement for an active proton delivery network supports a compound I-mediated C-C bond cleavage in CYP51 catalysis. | 14 |
| 29807244 | 2018 | Interaction of 17α-hydroxylase, 17(20)-lyase (CYP17A1) inhibitors - abiraterone and galeterone - with human sterol 14α-demethylase (CYP51A1). | 3 |
Citation
Dessen P
CYP51A1 (cytochrome P450 family 51 subfamily A member 1)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/62270/cyp51a1-(cytochrome-p450-family-51-subfamily-a-member-1)
