DCP2 (decapping mRNA 2)

2014-11-01  

Identity

HGNC
LOCATION
5q22.2
LOCUSID
ALIAS
NUDT20
FUSION GENES

Other Information

Locus ID:

NCBI: 167227
MIM: 609844
HGNC: 24452
Ensembl: ENSG00000172795

Variants:

dbSNP: 167227
ClinVar: 167227
TCGA: ENSG00000172795
COSMIC: DCP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172795ENST00000389063Q8IU60
ENSG00000172795ENST00000512751D6RCL0
ENSG00000172795ENST00000513585H0Y9T5
ENSG00000172795ENST00000515408Q8IU60

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Decapping complexKEGGhsa_M00395
Decapping complexKEGGM00395
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
PERK regulates gene expressionREACTOMER-HSA-381042
ATF4 activates genesREACTOMER-HSA-380994
Gene ExpressionREACTOMER-HSA-74160
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
mRNA decay by 5' to 3' exoribonucleaseREACTOMER-HSA-430039
Regulation of mRNA stability by proteins that bind AU-rich elementsREACTOMER-HSA-450531
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNAREACTOMER-HSA-450385
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNAREACTOMER-HSA-450513
KSRP (KHSRP) binds and destabilizes mRNAREACTOMER-HSA-450604

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
374370582023MOV10 recruits DCP2 to decap human LINE-1 RNA by forming large cytoplasmic granules with phase separation properties.3
374370582023MOV10 recruits DCP2 to decap human LINE-1 RNA by forming large cytoplasmic granules with phase separation properties.3
361302712022Intrinsically disordered regions of tristetraprolin and DCP2 directly interact to mediate decay of ARE-mRNA.0
361302712022Intrinsically disordered regions of tristetraprolin and DCP2 directly interact to mediate decay of ARE-mRNA.0
303649872018Human MARF1 is an endoribonuclease that interacts with the DCP1:2 decapping complex and degrades target mRNAs.14
303649872018Human MARF1 is an endoribonuclease that interacts with the DCP1:2 decapping complex and degrades target mRNAs.14
258701042015Competition between Decapping Complex Formation and Ubiquitin-Mediated Proteasomal Degradation Controls Human Dcp2 Decapping Activity.15
258701042015Competition between Decapping Complex Formation and Ubiquitin-Mediated Proteasomal Degradation Controls Human Dcp2 Decapping Activity.15
245101892014The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1.55
245101892014The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1.55
231153032013The RNA-binding protein Y14 inhibits mRNA decapping and modulates processing body formation.29
231153032013The RNA-binding protein Y14 inhibits mRNA decapping and modulates processing body formation.29
230850782012Structural basis of the PNRC2-mediated link between mrna surveillance and decapping.44
230850782012Structural basis of the PNRC2-mediated link between mrna surveillance and decapping.44
210709682010Multiple mRNA decapping enzymes in mammalian cells.91

Citation

Dessen P

DCP2 (decapping mRNA 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62333/dcp2-(decapping-mrna-2)