DDX50 (DExD-box helicase 50)

2014-11-01  

Identity

HGNC
DDX50
LOCATION
10q22.1
LOCUSID
79009
ALIAS
GU2,GUB,RH-II/GuB,mcdrh
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79009
MIM: 610373
HGNC: 17906
Ensembl: ENSG00000107625

Variants:

dbSNP: 79009
ClinVar: 79009
TCGA: ENSG00000107625
COSMIC: DDX50

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107625ENST00000373585Q9BQ39
ENSG00000107625ENST00000471475S4R3G6
ENSG00000107625ENST00000483593S4R3V4
ENSG00000107625ENST00000610822A0A087WVC1

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
352159082022DDX50 Is a Viral Restriction Factor That Enhances IRF3 Activation.6
352159082022DDX50 Is a Viral Restriction Factor That Enhances IRF3 Activation.6
281810362017DDX50 inhibits the replication of dengue virus 2 by upregulating IFN-β production.6
281810362017DDX50 inhibits the replication of dengue virus 2 by upregulating IFN-β production.6
186157152009Solution structure of the GUCT domain from human RNA helicase II/Gu beta reveals the RRM fold, but implausible RNA interactions.9
186157152009Solution structure of the GUCT domain from human RNA helicase II/Gu beta reveals the RRM fold, but implausible RNA interactions.9

Citation

Dessen P

DDX50 (DExD-box helicase 50)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62370/ddx50-(dexd-box-helicase-50)