DECR1 (2,4-dienoyl-CoA reductase 1)

2014-11-01 Affiliation

Identity

HGNC

DECR1

LOCATION

8q21.3

LOCUSID

1666

ALIAS

DECR,NADPH,SDR18C1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1666
MIM: 222745
HGNC: 2753
Ensembl: ENSG00000104325

Variants:

dbSNP: 1666
ClinVar: 1666
TCGA: ENSG00000104325
COSMIC: DECR1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000104325	ENST00000220764	Q16698
ENSG00000104325	ENST00000220764	A0A024R9D7
ENSG00000104325	ENST00000517314	E5RHR1
ENSG00000104325	ENST00000517597	E5RGS6
ENSG00000104325	ENST00000517761	E5RFV2
ENSG00000104325	ENST00000518725	E5RID6
ENSG00000104325	ENST00000519328	E5RGS6
ENSG00000104325	ENST00000519410	E5RJG7
ENSG00000104325	ENST00000520148	H0YAW3
ENSG00000104325	ENST00000520227	E5RJD2
ENSG00000104325	ENST00000521603	E5RGS6
ENSG00000104325	ENST00000522161	Q16698

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolism	REACTOME	R-HSA-535734
Mitochondrial Fatty Acid Beta-Oxidation	REACTOME	R-HSA-77289
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	REACTOME	R-HSA-77288

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
24326071	2014	Uric acid induces NADPH oxidase-independent neutrophil extracellular trap formation.	42
18193341	2008	Inflammatory manifestations in chronic granulomatous disease (CGD).	36
18568448	2008	Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease.	22
15531764	2005	Structure and reactivity of human mitochondrial 2,4-dienoyl-CoA reductase: enzyme-ligand interactions in a distinctive short-chain reductase active site.	18
22360420	2012	Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.	18
20877624	2010	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	17
18472006	2008	Maintenance of luminal NADPH in the endoplasmic reticulum promotes the survival of human neutrophil granulocytes.	12
19049547	2008	Association of acute ischemic stroke with the MTHFR C677T polymorphism but not with NOS3 gene polymorphisms in a Singapore population.	6
19773279	2009	Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.	6

Citation

Dessen P

DECR1 (2,4-dienoyl-CoA reductase 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62375/decr1-(2-4-dienoyl-coa-reductase-1)