DEDD2 (death effector domain containing 2)

2014-11-01  

Identity

HGNC
DEDD2
LOCATION
19q13.2
LOCUSID
162989
ALIAS
FLAME-3,FLAME3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 162989
MIM: 617078
HGNC: 24450
Ensembl: ENSG00000160570

Variants:

dbSNP: 162989
ClinVar: 162989
TCGA: ENSG00000160570
COSMIC: DEDD2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160570ENST00000336034Q8WXF8
ENSG00000160570ENST00000595337Q8WXF8
ENSG00000160570ENST00000596251Q8WXF8
ENSG00000160570ENST00000598200M0QYK9
ENSG00000160570ENST00000598727M0QXK7

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
125278982003DEDD and DEDD2 associate with caspase-8/10 and signal cell death.23
119654972002Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC.9

Citation

Dessen P

DEDD2 (death effector domain containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62378/dedd2-(death-effector-domain-containing-2)