Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 22898
MIM: 617503
HGNC: 29134
Ensembl: ENSG00000105339
Variants:
dbSNP: 22898
ClinVar: 22898
TCGA: ENSG00000105339
COSMIC: DENND3
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Vesicle-mediated transport | REACTOME | R-HSA-5653656 |
| Membrane Trafficking | REACTOME | R-HSA-199991 |
| RAB GEFs exchange GTP for GDP on RABs | REACTOME | R-HSA-8876198 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36729283 | 2023 | DENND3 p.L708V activating variant is involved in the pathogenesis of hereditary hemochromatosis via the RAB12/TFR2 signaling pathway. | 1 |
| 36729283 | 2023 | DENND3 p.L708V activating variant is involved in the pathogenesis of hereditary hemochromatosis via the RAB12/TFR2 signaling pathway. | 1 |
| 29352104 | 2018 | A PH-like domain of the Rab12 guanine nucleotide exchange factor DENND3 binds actin and is required for autophagy. | 9 |
| 29352104 | 2018 | A PH-like domain of the Rab12 guanine nucleotide exchange factor DENND3 binds actin and is required for autophagy. | 9 |
| 28249939 | 2017 | Regulation of DENND3, the exchange factor for the small GTPase Rab12 through an intramolecular interaction. | 7 |
| 28249939 | 2017 | Regulation of DENND3, the exchange factor for the small GTPase Rab12 through an intramolecular interaction. | 7 |
| 25925668 | 2015 | Phosphorylation of the exchange factor DENND3 by ULK in response to starvation activates Rab12 and induces autophagy. | 37 |
| 25925668 | 2015 | Phosphorylation of the exchange factor DENND3 by ULK in response to starvation activates Rab12 and induces autophagy. | 37 |
| 20379614 | 2010 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | 78 |
| 20379614 | 2010 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | 78 |
Citation
Dessen P
DENND3 (DENN domain containing 3)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/62431/submit-meetings/teaching-explorer/
