DGKH (diacylglycerol kinase eta)

2014-11-01  

Identity

HGNC
LOCATION
13q14.11
LOCUSID
ALIAS
DGKeta
FUSION GENES

Other Information

Locus ID:

NCBI: 160851
MIM: 604071
HGNC: 2854
Ensembl: ENSG00000102780

Variants:

dbSNP: 160851
ClinVar: 160851
TCGA: ENSG00000102780
COSMIC: DGKH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102780ENST00000261491Q86XP1
ENSG00000102780ENST00000337343Q86XP1
ENSG00000102780ENST00000379274Q86XP1
ENSG00000102780ENST00000536612Q86XP1
ENSG00000102780ENST00000611224A0A087WZ02
ENSG00000102780ENST00000626247A0A0D9SF65
ENSG00000102780ENST00000627777A0A0D9SFR6
ENSG00000102780ENST00000628433Q86XP1

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Glycerolipid metabolismKEGGko00561
Glycerophospholipid metabolismKEGGko00564
Phosphatidylinositol signaling systemKEGGko04070
Glycerolipid metabolismKEGGhsa00561
Glycerophospholipid metabolismKEGGhsa00564
Phosphatidylinositol signaling systemKEGGhsa04070
Metabolic pathwaysKEGGhsa01100
Choline metabolism in cancerKEGGhsa05231
Choline metabolism in cancerKEGGko05231
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Effects of PIP2 hydrolysisREACTOMER-HSA-114508
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
342932682021Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-Signaling.7
342932682021Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-Signaling.7
299363932018Implication of the DGKH genotype in openness to experience, a premorbid personality trait of bipolar disorder.2
299363932018Implication of the DGKH genotype in openness to experience, a premorbid personality trait of bipolar disorder.2
270853242017Expressional profile of the diacylglycerol kinase eta gene DGKH.2
270853242017Expressional profile of the diacylglycerol kinase eta gene DGKH.2
268879482016The Pleckstrin Homology Domain of Diacylglycerol Kinase η Strongly and Selectively Binds to Phosphatidylinositol 4,5-Bisphosphate.7
270166582016DGKH genetic risk variant influences gene expression in bipolar affective disorder.0
272555762016Whole-exome sequencing implicates DGKH as a risk gene for panic disorder in the Faroese population.7
268879482016The Pleckstrin Homology Domain of Diacylglycerol Kinase η Strongly and Selectively Binds to Phosphatidylinositol 4,5-Bisphosphate.7
270166582016DGKH genetic risk variant influences gene expression in bipolar affective disorder.0
272555762016Whole-exome sequencing implicates DGKH as a risk gene for panic disorder in the Faroese population.7
249584942015Influence of DGKH variants on amygdala volume in patients with bipolar affective disorder and schizophrenia.4
249584942015Influence of DGKH variants on amygdala volume in patients with bipolar affective disorder and schizophrenia.4
250813282014Association study of DGKH gene polymorphisms with calcium oxalate stone in Chinese population.4

Citation

Dessen P

DGKH (diacylglycerol kinase eta)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62456/dgkh-(diacylglycerol-kinase-eta)