DLK2 (delta like non-canonical Notch ligand 2)

2014-11-01  

Identity

HGNC
DLK2
LOCATION
6p21.1
LOCUSID
65989
ALIAS
DLK-2,EGFL9
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 65989
HGNC: 21113
Ensembl: ENSG00000171462

Variants:

dbSNP: 65989
ClinVar: 65989
TCGA: ENSG00000171462
COSMIC: DLK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171462ENST00000357338Q6UY11
ENSG00000171462ENST00000357338A0A024RD55
ENSG00000171462ENST00000372485Q5T3T9
ENSG00000171462ENST00000372488Q6UY11
ENSG00000171462ENST00000372488A0A024RD55
ENSG00000171462ENST00000430324H0Y5P1

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
351634782022Different Expression Levels of DLK2 Inhibit NOTCH Signaling and Inversely Modulate MDA-MB-231 Breast Cancer Tumor Growth In Vivo.1
351634782022Different Expression Levels of DLK2 Inhibit NOTCH Signaling and Inversely Modulate MDA-MB-231 Breast Cancer Tumor Growth In Vivo.1
316950342019EGFL9 promotes breast cancer metastasis by inducing cMET activation and metabolic reprogramming.22
316950342019EGFL9 promotes breast cancer metastasis by inducing cMET activation and metabolic reprogramming.22
173201022007The novel gene EGFL9/Dlk2, highly homologous to Dlk1, functions as a modulator of adipogenesis.17
173201022007The novel gene EGFL9/Dlk2, highly homologous to Dlk1, functions as a modulator of adipogenesis.17

Citation

Dessen P

DLK2 (delta like non-canonical Notch ligand 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62527/dlk2-(delta-like-non-canonical-notch-ligand-2)