DNAJC24 (DnaJ heat shock protein family (Hsp40) member C24)

2014-11-01  

Identity

HGNC
DNAJC24
LOCATION
11p13
LOCUSID
120526
ALIAS
DPH4,JJJ3,ZCSL3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 120526
MIM: 611072
HGNC: 26979
Ensembl: ENSG00000170946

Variants:

dbSNP: 120526
ClinVar: 120526
TCGA: ENSG00000170946
COSMIC: DNAJC24

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170946ENST00000395949J3KPT8
ENSG00000170946ENST00000465995Q6P3W2
ENSG00000170946ENST00000525511E9PID3
ENSG00000170946ENST00000526042Q6P3W2
ENSG00000170946ENST00000526042D3DQZ6
ENSG00000170946ENST00000526529E9PRW3
ENSG00000170946ENST00000527731H0YCV1

Expression (GTEx)

0
1
2
3
4
5
6
7
8
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Gamma carboxylation, hypusine formation and arylsulfatase activationREACTOMER-HSA-163841
Synthesis of diphthamide-EEF2REACTOMER-HSA-5358493

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
387131002024DNAJC24 acts directly with PCNA and promotes malignant progression of LUAD by activating phosphorylation of AKT.0
387131002024DNAJC24 acts directly with PCNA and promotes malignant progression of LUAD by activating phosphorylation of AKT.0
223671992012Structure and mechanistic insights into novel iron-mediated moonlighting functions of human J-protein cochaperone, Dph4.15
225090462012Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategy.28
223671992012Structure and mechanistic insights into novel iron-mediated moonlighting functions of human J-protein cochaperone, Dph4.15
225090462012Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategy.28

Citation

Dessen P

DNAJC24 (DnaJ heat shock protein family (Hsp40) member C24)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62564/dnajc24-(dnaj-heat-shock-protein-family-(hsp40)-member-c24)