DOCK7 (dedicator of cytokinesis 7)

2014-11-01  

Identity

HGNC
DOCK7
LOCATION
1p31.3
LOCUSID
85440
ALIAS
DEE23,EIEE23,ZIR2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 85440
MIM: 615730
HGNC: 19190
Ensembl: ENSG00000116641

Variants:

dbSNP: 85440
ClinVar: 85440
TCGA: ENSG00000116641
COSMIC: DOCK7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116641ENST00000251157Q96N67
ENSG00000116641ENST00000340370Q96N67
ENSG00000116641ENST00000404627Q96N67
ENSG00000116641ENST00000454575Q96N67
ENSG00000116641ENST00000464312A0A0U1RQT6
ENSG00000116641ENST00000614472A0A0C4DGY6
ENSG00000116641ENST00000634223A0A0U1RQG7
ENSG00000116641ENST00000634264Q96N67
ENSG00000116641ENST00000634652A0A0U1RRC1
ENSG00000116641ENST00000634929A0A0U1RQJ5
ENSG00000116641ENST00000635088A0A0U1RR97
ENSG00000116641ENST00000635123Q96N67
ENSG00000116641ENST00000635253Q96N67
ENSG00000116641ENST00000635827A0A1B0GVW2
ENSG00000116641ENST00000637208A0A1B0GUE9
ENSG00000116641ENST00000637255A0A1B0GWE0

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
Signal TransductionREACTOMER-HSA-162582
Signaling by METREACTOMER-HSA-6806834
MET promotes cell motilityREACTOMER-HSA-8875878
MET activates RAP1 and RAC1REACTOMER-HSA-8875555

References

Pubmed IDYearTitleCitations
383858572024Tumour-associated macrophage-derived DOCK7-enriched extracellular vesicles drive tumour metastasis in colorectal cancer via the RAC1/ABCA1 axis.2
383858572024Tumour-associated macrophage-derived DOCK7-enriched extracellular vesicles drive tumour metastasis in colorectal cancer via the RAC1/ABCA1 axis.2
334719542021Characteristic facial features and cortical blindness distinguish the DOCK7-related epileptic encephalopathy.2
337044642021DOCK7 protects against replication stress by promoting RPA stability on chromatin.9
334719542021Characteristic facial features and cortical blindness distinguish the DOCK7-related epileptic encephalopathy.2
337044642021DOCK7 protects against replication stress by promoting RPA stability on chromatin.9
308534112019Structural Basis for the Dual Substrate Specificity of DOCK7 Guanine Nucleotide Exchange Factor.12
308534112019Structural Basis for the Dual Substrate Specificity of DOCK7 Guanine Nucleotide Exchange Factor.12
291873802018Nbeal2 interacts with Dock7, Sec16a, and Vac14.11
294543882018DOCK7-ANGPTL3 SNPs and their haplotypes with serum lipid levels and the risk of coronary artery disease and ischemic stroke.14
291873802018Nbeal2 interacts with Dock7, Sec16a, and Vac14.11
294543882018DOCK7-ANGPTL3 SNPs and their haplotypes with serum lipid levels and the risk of coronary artery disease and ischemic stroke.14
264933512016Association of the variants and haplotypes in the DOCK7, PCSK9 and GALNT2 genes and the risk of hyperlipidaemia.16
267440842016Association between the DOCK7, PCSK9 and GALNT2 Gene Polymorphisms and Serum Lipid levels.24
270187472016Interaction of myosin VI and its binding partner DOCK7 plays an important role in NGF-stimulated protrusion formation in PC12 cells.10

Citation

Dessen P

DOCK7 (dedicator of cytokinesis 7)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62591/dock7-(dedicator-of-cytokinesis-7)