AMD1 (adenosylmethionine decarboxylase 1)

2003-06-01  

Identity

HGNC
AMD1
LOCATION
6q21
LOCUSID
262
ALIAS
ADOMETDC,AMD,SAMDC
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 262
MIM: 180980
HGNC: 457
Ensembl: ENSG00000123505

Variants:

dbSNP: 262
ClinVar: 262
TCGA: ENSG00000123505
COSMIC: AMD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123505ENST00000368876Q5VXN5
ENSG00000123505ENST00000368877Q5VXN5
ENSG00000123505ENST00000368882B4DZ60
ENSG00000123505ENST00000368885P17707
ENSG00000123505ENST00000451850F6R5I9

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Arginine and proline metabolismKEGGko00330
Arginine and proline metabolismKEGGhsa00330
Cysteine and methionine metabolismKEGGko00270
Cysteine and methionine metabolismKEGGhsa00270
Metabolic pathwaysKEGGhsa01100
Polyamine biosynthesis, arginine => agmatine => putrescine => spermidineKEGGhsa_M00133
Methionine salvage pathwayKEGGhsa_M00034
Methionine salvage pathwayKEGGM00034
Polyamine biosynthesis, arginine => agmatine => putrescine => spermidineKEGGM00133
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Metabolism of polyaminesREACTOMER-HSA-351202

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
386543322024AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis.2
386543322024AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis.2
332039902021AMD1 is required for the maintenance of leukemic stem cells and promotes chronic myeloid leukemic growth.6
332039902021AMD1 is required for the maintenance of leukemic stem cells and promotes chronic myeloid leukemic growth.6
311405542020Polyamine synthesis enzyme AMD1 is closely associated with tumorigenesis and prognosis of human gastric cancers.15
311405542020Polyamine synthesis enzyme AMD1 is closely associated with tumorigenesis and prognosis of human gastric cancers.15
306501902019Genetic variants in RUNX3, AMD1 and MSRA in the methionine metabolic pathway and survival in nonsmall cell lung cancer patients.0
306501902019Genetic variants in RUNX3, AMD1 and MSRA in the methionine metabolic pathway and survival in nonsmall cell lung cancer patients.0
293101202018AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation.32
299064102018Polyamine Regulator AMD1 Promotes Cell Migration in Epidermal Wound Healing.9
293101202018AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation.32
299064102018Polyamine Regulator AMD1 Promotes Cell Migration in Epidermal Wound Healing.9
286582052017mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.0
286582052017mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.0
265588252015Common variants in LEPR, IL6, AMD1, and NAMPT do not associate with risk of juvenile and childhood obesity in Danes: a case-control study.4

Citation

Dessen P

AMD1 (adenosylmethionine decarboxylase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/626/amd1-(adenosylmethionine-decarboxylase-1)