Identity
HGNC
LOCATION
21q22.2
LOCUSID
ALIAS
CHD2,CHD2-42,CHD2-52
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1826
MIM: 602523
HGNC: 3039
Ensembl: ENSG00000171587
Variants:
dbSNP: 1826
ClinVar: 1826
TCGA: ENSG00000171587
COSMIC: DSCAM
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000171587 | ENST00000400454 | O60469 |
| ENSG00000171587 | ENST00000404019 | Q8WY19 |
| ENSG00000171587 | ENST00000617870 | A0A087WUI7 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Cell-Cell communication | REACTOME | R-HSA-1500931 |
| DSCAM interactions | REACTOME | R-HSA-376172 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443622 | Carcinoma, Non-Small-Cell Lung | Disease | ClinicalAnnotation | associated | PD | 21079520 | |
| PA445062 | Neoplasms | Disease | ClinicalAnnotation | associated | PD | 21079520 | |
| PA448803 | carboplatin | Chemical | ClinicalAnnotation | associated | PD | 21079520 | |
| PA450761 | paclitaxel | Chemical | ClinicalAnnotation | associated | PD | 21079520 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38828726 | 2024 | Increased endothelial sclerostin caused by elevated DSCAM mediates multiple trisomy 21 phenotypes. | 0 |
| 38828726 | 2024 | Increased endothelial sclerostin caused by elevated DSCAM mediates multiple trisomy 21 phenotypes. | 0 |
| 33945512 | 2021 | DSCAM/PAK1 pathway suppression reverses neurogenesis deficits in iPSC-derived cerebral organoids from patients with Down syndrome. | 48 |
| 34253863 | 2021 | Dysfunction of NMDA receptors in neuronal models of an autism spectrum disorder patient with a DSCAM mutation and in Dscam-knockout mice. | 6 |
| 34372727 | 2021 | Long non-coding RNA Down syndrome cell adhesion molecule-anti-sense 1 promotes gastric carcinoma cell proliferation and migration by regulating the miR-204/TPT1 axis. | 2 |
| 34445216 | 2021 | Role of DSCAM in the Development of Neural Control of Movement and Locomotion. | 3 |
| 33945512 | 2021 | DSCAM/PAK1 pathway suppression reverses neurogenesis deficits in iPSC-derived cerebral organoids from patients with Down syndrome. | 48 |
| 34253863 | 2021 | Dysfunction of NMDA receptors in neuronal models of an autism spectrum disorder patient with a DSCAM mutation and in Dscam-knockout mice. | 6 |
| 34372727 | 2021 | Long non-coding RNA Down syndrome cell adhesion molecule-anti-sense 1 promotes gastric carcinoma cell proliferation and migration by regulating the miR-204/TPT1 axis. | 2 |
| 34445216 | 2021 | Role of DSCAM in the Development of Neural Control of Movement and Locomotion. | 3 |
| 31737900 | 2020 | Long non-coding RNA DSCAM-AS1 contributes to the tumorigenesis of cervical cancer by targeting miR-877-5p/ATXN7L3 axis. | 27 |
| 31737900 | 2020 | Long non-coding RNA DSCAM-AS1 contributes to the tumorigenesis of cervical cancer by targeting miR-877-5p/ATXN7L3 axis. | 27 |
| 30206355 | 2019 | A genome-wide search for new imprinted genes in the human placenta identifies DSCAM as the first imprinted gene on chromosome 21. | 6 |
| 30541104 | 2019 | Plasmid-based gap-repair recombineered transgenes reveal a central role for introns in mutually exclusive alternative splicing in Down Syndrome Cell Adhesion Molecule exon 4. | 8 |
| 30206355 | 2019 | A genome-wide search for new imprinted genes in the human placenta identifies DSCAM as the first imprinted gene on chromosome 21. | 6 |
Citation
Dessen P
DSCAM (DS cell adhesion molecule)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/62647/dscam-(ds-cell-adhesion-molecule)
