DYNC1LI2 (dynein cytoplasmic 1 light intermediate chain 2)

2014-11-01  

Identity

HGNC
DYNC1LI2
LOCATION
16q22.1
LOCUSID
1783
ALIAS
DNCLI2,LIC2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1783
MIM: 611406
HGNC: 2966
Ensembl: ENSG00000135720

Variants:

dbSNP: 1783
ClinVar: 1783
TCGA: ENSG00000135720
COSMIC: DYNC1LI2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135720ENST00000258198O43237
ENSG00000135720ENST00000258198A0A024R6Z0
ENSG00000135720ENST00000440564B4E2E0
ENSG00000135720ENST00000443351O43237
ENSG00000135720ENST00000563628J3KSD2
ENSG00000135720ENST00000564090J3QKK5
ENSG00000135720ENST00000564559J3KRZ2
ENSG00000135720ENST00000566150H3BUM4
ENSG00000135720ENST00000568180H3BU48
ENSG00000135720ENST00000569320J3KRI4

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vasopressin-regulated water reabsorptionKEGGko04962
Vasopressin-regulated water reabsorptionKEGGhsa04962
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
COPI-mediated anterograde transportREACTOMER-HSA-6807878
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-independent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811436

References

Pubmed IDYearTitleCitations
211695572011Recruitment of dynein to late endosomes and lysosomes through light intermediate chains.37
202148882010Rab11-FIP3 binds dynein light intermediate chain 2 and its overexpression fragments the Golgi complex.23
254223742014Dynein light intermediate chains maintain spindle bipolarity by functioning in centriole cohesion.9
274415622016Dynein Light Intermediate Chain 2 Facilitates the Metaphase to Anaphase Transition by Inactivating the Spindle Assembly Checkpoint.5
280036572016The Light Intermediate Chain 2 Subpopulation of Dynein Regulates Mitotic Spindle Orientation.5
274338482016BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein.4

Citation

Dessen P

DYNC1LI2 (dynein cytoplasmic 1 light intermediate chain 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62690/dync1li2-(dynein-cytoplasmic-1-light-intermediate-chain-2)