DYNLL2 (dynein light chain LC8-type 2)

2014-11-01 Affiliation

Identity

HGNC

DYNLL2

LOCATION

17q22

LOCUSID

140735

ALIAS

DNCL1B,Dlc2,RSPH22

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 140735
MIM: 608942
HGNC: 24596
Ensembl: ENSG00000264364

Variants:

dbSNP: 140735
ClinVar: 140735
TCGA: ENSG00000264364
COSMIC: DYNLL2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000264364	ENST00000579991	Q96FJ2

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Vasopressin-regulated water reabsorption	KEGG	ko04962
Vasopressin-regulated water reabsorption	KEGG	hsa04962
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Asparagine N-linked glycosylation	REACTOME	R-HSA-446203
Transport to the Golgi and subsequent modification	REACTOME	R-HSA-948021
ER to Golgi Anterograde Transport	REACTOME	R-HSA-199977
Organelle biogenesis and maintenance	REACTOME	R-HSA-1852241
Cilium Assembly	REACTOME	R-HSA-5617833
Intraflagellar transport	REACTOME	R-HSA-5620924
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
MHC class II antigen presentation	REACTOME	R-HSA-2132295
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
Programmed Cell Death	REACTOME	R-HSA-5357801
Apoptosis	REACTOME	R-HSA-109581
Intrinsic Pathway for Apoptosis	REACTOME	R-HSA-109606
Activation of BH3-only proteins	REACTOME	R-HSA-114452
Activation of BMF and translocation to mitochondria	REACTOME	R-HSA-139910
Cellular responses to stress	REACTOME	R-HSA-2262752
Macroautophagy	REACTOME	R-HSA-1632852
COPI-mediated anterograde transport	REACTOME	R-HSA-6807878
Intra-Golgi and retrograde Golgi-to-ER traffic	REACTOME	R-HSA-6811442
Golgi-to-ER retrograde transport	REACTOME	R-HSA-8856688
COPI-independent Golgi-to-ER retrograde traffic	REACTOME	R-HSA-6811436

References

Pubmed ID	Year	Title	Citations
25312846	2014	DYNLL2 dynein light chain binds to an extended linear motif of myosin 5a tail that has structural plasticity.	10
25312846	2014	DYNLL2 dynein light chain binds to an extended linear motif of myosin 5a tail that has structural plasticity.	10
20889982	2010	Affinity, avidity, and kinetics of target sequence binding to LC8 dynein light chain isoforms.	18
20889982	2010	Affinity, avidity, and kinetics of target sequence binding to LC8 dynein light chain isoforms.	18

Citation

Dessen P

DYNLL2 (dynein light chain LC8-type 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62693/dynll2-(dynein-light-chain-lc8-type-2)

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