EDC3 (enhancer of mRNA decapping 3)

2014-11-01  

Identity

HGNC
EDC3
LOCATION
15q24.1
LOCUSID
80153
ALIAS
LSM16,MRT50,YJDC,YJEFN2,hYjeF_N2-15q23
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 80153
MIM: 609842
HGNC: 26114
Ensembl: ENSG00000179151

Variants:

dbSNP: 80153
ClinVar: 80153
TCGA: ENSG00000179151
COSMIC: EDC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179151ENST00000315127Q96F86
ENSG00000179151ENST00000426797Q96F86
ENSG00000179151ENST00000562174H3BPN4
ENSG00000179151ENST00000562974H3BTD6
ENSG00000179151ENST00000563009H3BPW9
ENSG00000179151ENST00000563292H3BMB8
ENSG00000179151ENST00000565602H3BNJ7
ENSG00000179151ENST00000566119H3BQA1
ENSG00000179151ENST00000566219H3BSQ0
ENSG00000179151ENST00000566243H3BU87
ENSG00000179151ENST00000566828H3BQP5
ENSG00000179151ENST00000567813H3BTF8
ENSG00000179151ENST00000568176Q96F86
ENSG00000179151ENST00000569561H3BQ37
ENSG00000179151ENST00000570138H3BTH0
ENSG00000179151ENST00000647659Q96F86

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Decapping complexKEGGhsa_M00395
Decapping complexKEGGM00395
Gene ExpressionREACTOMER-HSA-74160
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
mRNA decay by 5' to 3' exoribonucleaseREACTOMER-HSA-430039

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
192859482009Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B.60
179236972007A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting.31
186786522008Crystal structure of human Edc3 and its functional implications.29
257018702015Mutations in DCPS and EDC3 in autosomal recessive intellectual disability indicate a crucial role for mRNA decapping in neurodevelopment.14
296851332018Integrative bioinformatics analysis characterizing the role of EDC3 in mRNA decay and its association to intellectual disability.3

Citation

Dessen P

EDC3 (enhancer of mRNA decapping 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62723/edc3-(enhancer-of-mrna-decapping-3)