EDC3 (enhancer of mRNA decapping 3)

2014-11-01 Affiliation

Identity

HGNC

EDC3

LOCATION

15q24.1

LOCUSID

80153

ALIAS

LSM16,MRT50,YJDC,YJEFN2,hYjeF_N2-15q23

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 80153
MIM: 609842
HGNC: 26114
Ensembl: ENSG00000179151

Variants:

dbSNP: 80153
ClinVar: 80153
TCGA: ENSG00000179151
COSMIC: EDC3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000179151	ENST00000315127	Q96F86
ENSG00000179151	ENST00000426797	Q96F86
ENSG00000179151	ENST00000562174	H3BPN4
ENSG00000179151	ENST00000562974	H3BTD6
ENSG00000179151	ENST00000563009	H3BPW9
ENSG00000179151	ENST00000563292	H3BMB8
ENSG00000179151	ENST00000565602	H3BNJ7
ENSG00000179151	ENST00000566119	H3BQA1
ENSG00000179151	ENST00000566219	H3BSQ0
ENSG00000179151	ENST00000566243	H3BU87
ENSG00000179151	ENST00000566828	H3BQP5
ENSG00000179151	ENST00000567813	H3BTF8
ENSG00000179151	ENST00000568176	Q96F86
ENSG00000179151	ENST00000569561	H3BQ37
ENSG00000179151	ENST00000570138	H3BTH0
ENSG00000179151	ENST00000647659	Q96F86

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
RNA degradation	KEGG	ko03018
RNA degradation	KEGG	hsa03018
Decapping complex	KEGG	hsa_M00395
Decapping complex	KEGG	M00395
Gene Expression	REACTOME	R-HSA-74160
Deadenylation-dependent mRNA decay	REACTOME	R-HSA-429914
mRNA decay by 5' to 3' exoribonuclease	REACTOME	R-HSA-430039

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
29685133	2018	Integrative bioinformatics analysis characterizing the role of EDC3 in mRNA decay and its association to intellectual disability.	5
29685133	2018	Integrative bioinformatics analysis characterizing the role of EDC3 in mRNA decay and its association to intellectual disability.	5
25701870	2015	Mutations in DCPS and EDC3 in autosomal recessive intellectual disability indicate a crucial role for mRNA decapping in neurodevelopment.	27
25701870	2015	Mutations in DCPS and EDC3 in autosomal recessive intellectual disability indicate a crucial role for mRNA decapping in neurodevelopment.	27
19285948	2009	Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B.	75
19285948	2009	Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B.	75
18678652	2008	Crystal structure of human Edc3 and its functional implications.	44
18678652	2008	Crystal structure of human Edc3 and its functional implications.	44
17923697	2007	A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting.	40
17923697	2007	A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting.	40

Citation

Dessen P

EDC3 (enhancer of mRNA decapping 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62723/edc3-(enhancer-of-mrna-decapping-3)