Identity
HGNC
LOCATION
16q22.1
LOCUSID
ALIAS
GE1,Ge-1,HEDL5,HEDLS,RCD-8,RCD8
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 23644
MIM: 606030
HGNC: 17157
Ensembl: ENSG00000038358
Variants:
dbSNP: 23644
ClinVar: 23644
TCGA: ENSG00000038358
COSMIC: EDC4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000038358 | ENST00000358933 | Q6P2E9 |
| ENSG00000038358 | ENST00000573985 | I3L0V0 |
| ENSG00000038358 | ENST00000575033 | I3L3M2 |
| ENSG00000038358 | ENST00000577105 | I3L2F4 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32510323 | 2020 | A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay. | 8 |
| 33054858 | 2020 | Enhancer of mRNA Decapping protein 4 (EDC4) interacts with replication protein a (RPA) and contributes to Cisplatin resistance in cervical Cancer by alleviating DNA damage. | 5 |
| 32510323 | 2020 | A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay. | 8 |
| 33054858 | 2020 | Enhancer of mRNA Decapping protein 4 (EDC4) interacts with replication protein a (RPA) and contributes to Cisplatin resistance in cervical Cancer by alleviating DNA damage. | 5 |
| 29511213 | 2018 | Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1. | 20 |
| 29511213 | 2018 | Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1. | 20 |
| 25970328 | 2015 | The Assembly of EDC4 and Dcp1a into Processing Bodies Is Critical for the Translational Regulation of IL-6. | 10 |
| 25970328 | 2015 | The Assembly of EDC4 and Dcp1a into Processing Bodies Is Critical for the Translational Regulation of IL-6. | 10 |
| 24510189 | 2014 | The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1. | 55 |
| 24755989 | 2014 | LMKB/MARF1 localizes to mRNA processing bodies, interacts with Ge-1, and regulates IFI44L gene expression. | 12 |
| 24858563 | 2014 | CCHCR1 interacts with EDC4, suggesting its localization in P-bodies. | 12 |
| 24510189 | 2014 | The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1. | 55 |
| 24755989 | 2014 | LMKB/MARF1 localizes to mRNA processing bodies, interacts with Ge-1, and regulates IFI44L gene expression. | 12 |
| 24858563 | 2014 | CCHCR1 interacts with EDC4, suggesting its localization in P-bodies. | 12 |
| 22982864 | 2012 | EDC4 interacts with and regulates the dephospho-CoA kinase activity of CoA synthase. | 12 |
Citation
Dessen P
EDC4 (enhancer of mRNA decapping 4)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/62724/chromosome-explorer/new-content/
