Identity
HGNC
LOCATION
20q11.22
LOCUSID
ALIAS
C20orf31,C20orf49,bA4204.1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 55741
MIM: 610302
HGNC: 15877
Ensembl: ENSG00000088298
Variants:
dbSNP: 55741
ClinVar: 55741
TCGA: ENSG00000088298
COSMIC: EDEM2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000088298 | ENST00000374491 | Q9BV94 |
| ENSG00000088298 | ENST00000374492 | Q9BV94 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32065582 | 2020 | EDEM2 stably disulfide-bonded to TXNDC11 catalyzes the first mannose trimming step in mammalian glycoprotein ERAD. | 16 |
| 32556999 | 2020 | A novel gene in early childhood diabetes: EDEM2 silencing decreases SLC2A2 and PXD1 expression, leading to impaired insulin secretion. | 4 |
| 32065582 | 2020 | EDEM2 stably disulfide-bonded to TXNDC11 catalyzes the first mannose trimming step in mammalian glycoprotein ERAD. | 16 |
| 32556999 | 2020 | A novel gene in early childhood diabetes: EDEM2 silencing decreases SLC2A2 and PXD1 expression, leading to impaired insulin secretion. | 4 |
| 24910992 | 2014 | EDEM2 and OS-9 are required for ER-associated degradation of non-glycosylated sonic hedgehog. | 18 |
| 25092655 | 2014 | EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step. | 70 |
| 24910992 | 2014 | EDEM2 and OS-9 are required for ER-associated degradation of non-glycosylated sonic hedgehog. | 18 |
| 25092655 | 2014 | EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step. | 70 |
| 20802025 | 2010 | Genome-wide association study identifies novel loci for plasma levels of protein C: the ARIC study. | 36 |
| 20802025 | 2010 | Genome-wide association study identifies novel loci for plasma levels of protein C: the ARIC study. | 36 |
| 15537790 | 2005 | Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins. | 68 |
| 15537790 | 2005 | Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins. | 68 |
| 15579471 | 2005 | A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation. | 67 |
| 15537790 | 2005 | Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins. | 68 |
| 15537790 | 2005 | Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins. | 68 |
Citation
Dessen P
EDEM2 (ER degradation enhancing alpha-mannosidase like protein 2)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/62727/edem2-(er-degradation-enhancing-alpha-mannosidase-like-protein-2)
