EIF3G (eukaryotic translation initiation factor 3 subunit G)

2014-11-01 Affiliation

Identity

HGNC

EIF3G

LOCATION

19p13.2

LOCUSID

8666

ALIAS

EIF3-P42,EIF3S4,eIF3-delta,eIF3-p44

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8666
MIM: 603913
HGNC: 3274
Ensembl: ENSG00000130811

Variants:

dbSNP: 8666
ClinVar: 8666
TCGA: ENSG00000130811
COSMIC: EIF3G

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000130811	ENST00000253108	O75821
ENSG00000130811	ENST00000587146	K7ER90
ENSG00000130811	ENST00000587993	K7ERL8
ENSG00000130811	ENST00000588709	K7EL20
ENSG00000130811	ENST00000589454	K7ENA8
ENSG00000130811	ENST00000593054	K7EP16
ENSG00000130811	ENST00000593066	K7ENH0
ENSG00000130811	ENST00000593095	K7EL60

Expression (GTEx)

100

150

200

250

300

350

400

450

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
RNA transport	KEGG	ko03013
RNA transport	KEGG	hsa03013
Metabolism of proteins	REACTOME	R-HSA-392499
Translation	REACTOME	R-HSA-72766
Eukaryotic Translation Initiation	REACTOME	R-HSA-72613
Cap-dependent Translation Initiation	REACTOME	R-HSA-72737
Formation of a pool of free 40S subunits	REACTOME	R-HSA-72689
Formation of the ternary complex, and subsequently, the 43S complex	REACTOME	R-HSA-72695
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	REACTOME	R-HSA-72662
Translation initiation complex formation	REACTOME	R-HSA-72649
Ribosomal scanning and start codon recognition	REACTOME	R-HSA-72702
GTP hydrolysis and joining of the 60S ribosomal subunit	REACTOME	R-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expression	REACTOME	R-HSA-156827
Gene Expression	REACTOME	R-HSA-74160

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
16243297	2005	A functional link between Disrupted-In-Schizophrenia 1 and the eukaryotic translation initiation factor 3.	22
22493286	2012	Translation initiation on mRNAs bound by nuclear cap-binding protein complex CBP80/20 requires interaction between CBP80/20-dependent translation initiation factor and eukaryotic translation initiation factor 3g.	19
17094969	2006	Apoptosis-inducing factor (AIF) inhibits protein synthesis by interacting with the eukaryotic translation initiation factor 3 subunit p44 (eIF3g).	9
20406461	2010	Pelota interacts with HAX1, EIF3G and SRPX and the resulting protein complexes are associated with the actin cytoskeleton.	7
25669430	2015	EIF3G is associated with narcolepsy across ethnicities.	7
24080033	2013	Caspase-mediated cleavage and DNase activity of the translation initiation factor 3, subunit G (eIF3g).	3

Citation

Dessen P

EIF3G (eukaryotic translation initiation factor 3 subunit G)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62780/eif3g-(eukaryotic-translation-initiation-factor-3-subunit-g)