EIF3G (eukaryotic translation initiation factor 3 subunit G)

2014-11-01  

Identity

HGNC
LOCATION
19p13.2
LOCUSID
ALIAS
EIF3-P42,EIF3S4,eIF3-delta,eIF3-p44
FUSION GENES

Other Information

Locus ID:

NCBI: 8666
MIM: 603913
HGNC: 3274
Ensembl: ENSG00000130811

Variants:

dbSNP: 8666
ClinVar: 8666
TCGA: ENSG00000130811
COSMIC: EIF3G

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130811ENST00000253108O75821
ENSG00000130811ENST00000587146K7ER90
ENSG00000130811ENST00000587993K7ERL8
ENSG00000130811ENST00000588709K7EL20
ENSG00000130811ENST00000589454K7ENA8
ENSG00000130811ENST00000593054K7EP16
ENSG00000130811ENST00000593066K7ENH0
ENSG00000130811ENST00000593095K7EL60

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
Formation of a pool of free 40S subunitsREACTOMER-HSA-72689
Formation of the ternary complex, and subsequently, the 43S complexREACTOMER-HSA-72695
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SREACTOMER-HSA-72662
Translation initiation complex formationREACTOMER-HSA-72649
Ribosomal scanning and start codon recognitionREACTOMER-HSA-72702
GTP hydrolysis and joining of the 60S ribosomal subunitREACTOMER-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expressionREACTOMER-HSA-156827
Gene ExpressionREACTOMER-HSA-74160

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
378118802023An interaction between eIF4A3 and eIF3g drives the internal initiation of translation.2
378211062023In vitro reconstitution of SARS-CoV-2 Nsp1-induced mRNA cleavage reveals the key roles of the N-terminal domain of Nsp1 and the RRM domain of eIF3g.4
378118802023An interaction between eIF4A3 and eIF3g drives the internal initiation of translation.2
378211062023In vitro reconstitution of SARS-CoV-2 Nsp1-induced mRNA cleavage reveals the key roles of the N-terminal domain of Nsp1 and the RRM domain of eIF3g.4
256694302015EIF3G is associated with narcolepsy across ethnicities.13
256694302015EIF3G is associated with narcolepsy across ethnicities.13
240800332013Caspase-mediated cleavage and DNase activity of the translation initiation factor 3, subunit G (eIF3g).5
240800332013Caspase-mediated cleavage and DNase activity of the translation initiation factor 3, subunit G (eIF3g).5
224932862012Translation initiation on mRNAs bound by nuclear cap-binding protein complex CBP80/20 requires interaction between CBP80/20-dependent translation initiation factor and eukaryotic translation initiation factor 3g.30
224932862012Translation initiation on mRNAs bound by nuclear cap-binding protein complex CBP80/20 requires interaction between CBP80/20-dependent translation initiation factor and eukaryotic translation initiation factor 3g.30
204064612010Pelota interacts with HAX1, EIF3G and SRPX and the resulting protein complexes are associated with the actin cytoskeleton.10
204064612010Pelota interacts with HAX1, EIF3G and SRPX and the resulting protein complexes are associated with the actin cytoskeleton.10
170949692006Apoptosis-inducing factor (AIF) inhibits protein synthesis by interacting with the eukaryotic translation initiation factor 3 subunit p44 (eIF3g).12
170949692006Apoptosis-inducing factor (AIF) inhibits protein synthesis by interacting with the eukaryotic translation initiation factor 3 subunit p44 (eIF3g).12
162432972005A functional link between Disrupted-In-Schizophrenia 1 and the eukaryotic translation initiation factor 3.24

Citation

Dessen P

EIF3G (eukaryotic translation initiation factor 3 subunit G)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62780/eif3g-(eukaryotic-translation-initiation-factor-3-subunit-g)