EIF4ENIF1 (eukaryotic translation initiation factor 4E nuclear import factor 1)

2014-11-01  

Identity

HGNC
LOCATION
22q12.2
LOCUSID
ALIAS
4E-T,Clast4
FUSION GENES

Other Information

Locus ID:

NCBI: 56478
MIM: 607445
HGNC: 16687
Ensembl: ENSG00000184708

Variants:

dbSNP: 56478
ClinVar: 56478
TCGA: ENSG00000184708
COSMIC: EIF4ENIF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184708ENST00000330125Q9NRA8
ENSG00000184708ENST00000330125A0A024R1K0
ENSG00000184708ENST00000344710Q9NRA8
ENSG00000184708ENST00000397518B1AKL6
ENSG00000184708ENST00000397520B1AKL6
ENSG00000184708ENST00000397523B1AKL4
ENSG00000184708ENST00000397525Q9NRA8
ENSG00000184708ENST00000397525A0A024R1K0
ENSG00000184708ENST00000418321B0QYZ7
ENSG00000184708ENST00000423097B1AKL5
ENSG00000184708ENST00000445424H7C0J7

Expression (GTEx)

0
10
20
30
40
50
60
70

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
158408192005A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies.159
161577022005A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay.94
260279252015The eIF4E-Binding Protein 4E-T Is a Component of the mRNA Decay Machinery that Bridges the 5' and 3' Termini of Target mRNAs.32
254564982014An eIF4E1/4E-T complex determines the genesis of neurons from precursors by translationally repressing a proneurogenic transcription program.30
243352852014Human 4E-T represses translation of bound mRNAs and enhances microRNA-mediated silencing.27
273422812016The DDX6-4E-T interaction mediates translational repression and P-body assembly.26
229662012012Phosphorylation of the eukaryotic translation initiation factor 4E-transporter (4E-T) by c-Jun N-terminal kinase promotes stress-dependent P-body assembly.17
239029452013Mutations in eIF4ENIF1 are associated with primary ovarian insufficiency.15
198509292009The Hsp90 inhibitor geldanamycin abrogates colocalization of eIF4E and eIF4E-transporter into stress granules and association of eIF4E with eIF4G.14
239911492013Investigating the consequences of eIF4E2 (4EHP) interaction with 4E-transporter on its cellular distribution in HeLa cells.13

Citation

Dessen P

EIF4ENIF1 (eukaryotic translation initiation factor 4E nuclear import factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62785/eif4enif1-(eukaryotic-translation-initiation-factor-4e-nuclear-import-factor-1)