ENTPD4 (ectonucleoside triphosphate diphosphohydrolase 4)

2014-11-01  

Identity

HGNC
ENTPD4
LOCATION
8p21.3
LOCUSID
9583
ALIAS
LALP70,LAP70,LYSAL1,NTPDase-4,UDPase
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9583
MIM: 607577
HGNC: 14573
Ensembl: ENSG00000197217

Variants:

dbSNP: 9583
ClinVar: 9583
TCGA: ENSG00000197217
COSMIC: ENTPD4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197217ENST00000356206Q8NE73
ENSG00000197217ENST00000358689Q9Y227
ENSG00000197217ENST00000417069Q9Y227
ENSG00000197217ENST00000518471H0YBY8
ENSG00000197217ENST00000518718E5RIB2
ENSG00000197217ENST00000519839H0YAN2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Pyrimidine metabolismKEGGko00240
Purine metabolismKEGGhsa00230
Pyrimidine metabolismKEGGhsa00240
LysosomeKEGGko04142
LysosomeKEGGhsa04142
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Phosphate bond hydrolysis by NTPDase proteinsREACTOMER-HSA-8850843

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil

References

Pubmed IDYearTitleCitations
327674322020Crystal structure of the nucleotide-metabolizing enzyme NTPDase4.4
327674322020Crystal structure of the nucleotide-metabolizing enzyme NTPDase4.4
246720252014NTPDASE4 gene products cooperate with the adenovirus E4orf4 protein through PP2A-dependent and -independent mechanisms and contribute to induction of cell death.5
246720252014NTPDASE4 gene products cooperate with the adenovirus E4orf4 protein through PP2A-dependent and -independent mechanisms and contribute to induction of cell death.5
205377212011An association study on polymorphisms in the PEA15, ENTPD4, and GAS2L1 genes and schizophrenia.7
205377212011An association study on polymorphisms in the PEA15, ENTPD4, and GAS2L1 genes and schizophrenia.7
205377212011An association study on polymorphisms in the PEA15, ENTPD4, and GAS2L1 genes and schizophrenia.7
205377212011An association study on polymorphisms in the PEA15, ENTPD4, and GAS2L1 genes and schizophrenia.7
202019262010Human variation in alcohol response is influenced by variation in neuronal signaling genes.52
202019262010Human variation in alcohol response is influenced by variation in neuronal signaling genes.52
152006862004The VSFASSQQ motif confers calcium sensitivity to the intracellular apyrase LALP70.4
152006862004The VSFASSQQ motif confers calcium sensitivity to the intracellular apyrase LALP70.4

Citation

Dessen P

ENTPD4 (ectonucleoside triphosphate diphosphohydrolase 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62845/tumors-explorer/teaching-explorer/