EXOC6 (exocyst complex component 6)

2014-11-01  

Identity

HGNC
EXOC6
LOCATION
10q23.33
LOCUSID
54536
ALIAS
EXOC6A,SEC15,SEC15L,SEC15L1,SEC15L3,Sec15p
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54536
MIM: 609672
HGNC: 23196
Ensembl: ENSG00000138190

Variants:

dbSNP: 54536
ClinVar: 54536
TCGA: ENSG00000138190
COSMIC: EXOC6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138190ENST00000260762Q8TAG9
ENSG00000138190ENST00000371543B1AP46
ENSG00000138190ENST00000371552Q8TAG9
ENSG00000138190ENST00000443748E7EW84
ENSG00000138190ENST00000458552H0Y5J8
ENSG00000138190ENST00000495132F2Z3K0

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Insulin processingREACTOMER-HSA-264876
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Cargo trafficking to the periciliary membraneREACTOMER-HSA-5620920
VxPx cargo-targeting to ciliumREACTOMER-HSA-5620916
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
152922012004Sec15 is an effector for the Rab11 GTPase in mammalian cells.108
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
209447472010Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst.50
234355662013NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by switching binding specificity from phosphatidylserine to Sec15.43
164787832006The polarity-establishment component Bem1p interacts with the exocyst complex through the Sec15p subunit.22
210443672010An integrative method for scoring candidate genes from association studies: application to warfarin dosing.11

Citation

Dessen P

EXOC6 (exocyst complex component 6)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62946/exoc6-(exocyst-complex-component-6)