F8A1 (coagulation factor VIII associated 1)

2014-11-01  

Identity

HGNC
LOCATION
Xq28
LOCUSID
ALIAS
DXS522E,F8A,HAP40

Other Information

Locus ID:

NCBI: 8263
MIM: 305423
HGNC: 3547
Ensembl: ENSG00000277203

Variants:

dbSNP: 8263
ClinVar: 8263
TCGA: ENSG00000277203
COSMIC: F8A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000277203ENST00000610495P23610

Expression (GTEx)

0
5
10
15
20

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
358530022022HAP40 is a conserved central regulator of Huntingtin and a potential modulator of Huntington's disease pathogenesis.6
358713602022Huntingtin and Its Partner Huntingtin-Associated Protein 40: Structural and Functional Considerations in Health and Disease.2
358530022022HAP40 is a conserved central regulator of Huntingtin and a potential modulator of Huntington's disease pathogenesis.6
358713602022Huntingtin and Its Partner Huntingtin-Associated Protein 40: Structural and Functional Considerations in Health and Disease.2
339099942021Pathological polyQ expansion does not alter the conformation of the Huntingtin-HAP40 complex.9
343908352021HAP40 protein levels are huntingtin-dependent and decrease in Huntington disease.7
339099942021Pathological polyQ expansion does not alter the conformation of the Huntingtin-HAP40 complex.9
343908352021HAP40 protein levels are huntingtin-dependent and decrease in Huntington disease.7
235210922013Molecular orientation of factor VIIIa on the phospholipid membrane surface determined by fluorescence resonance energy transfer.11
235210922013Molecular orientation of factor VIIIa on the phospholipid membrane surface determined by fluorescence resonance energy transfer.11
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
182993312008Identification of residues contributing to A2 domain-dependent structural stability in factor VIII and factor VIIIa.19

Citation

Dessen P

F8A1 (coagulation factor VIII associated 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62962/f8a1-(coagulation-factor-viii-associated-1)