FARP2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2)

2014-11-01 Affiliation

Identity

HGNC

FARP2

LOCATION

2q37.3

LOCUSID

9855

ALIAS

FIR,FRG,PLEKHC3

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9855
MIM: 617586
HGNC: 16460
Ensembl: ENSG00000006607

Variants:

dbSNP: 9855
ClinVar: 9855
TCGA: ENSG00000006607
COSMIC: FARP2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000006607	ENST00000264042	O94887
ENSG00000006607	ENST00000373287	O94887
ENSG00000006607	ENST00000412332	H7C210
ENSG00000006607	ENST00000413432	H7C3M7
ENSG00000006607	ENST00000418082	C9JVQ5
ENSG00000006607	ENST00000422951	H7C3E4
ENSG00000006607	ENST00000444371	H7C447
ENSG00000006607	ENST00000445489	C9JWM9
ENSG00000006607	ENST00000627550	O94887

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Adherens junction	KEGG	ko04520
Adherens junction	KEGG	hsa04520
Rap1 signaling pathway	KEGG	hsa04015
Rap1 signaling pathway	KEGG	ko04015
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
Semaphorin interactions	REACTOME	R-HSA-373755
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	REACTOME	R-HSA-399955

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA447197	Attention Deficit Disorder with Hyperactivity	Disease	ClinicalAnnotation, VariantAnnotation	associated		PD	29382897
PA450464	methylphenidate	Chemical	ClinicalAnnotation, VariantAnnotation	associated		PD	29382897

References

Pubmed ID	Year	Title	Citations
30872454	2019	The Rho family GEF FARP2 is activated by aPKCι to control tight junction formation and polarity.	7
30872454	2019	The Rho family GEF FARP2 is activated by aPKCι to control tight junction formation and polarity.	7
20062064	2010	Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk.	114
20468071	2010	Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts.	22
20855867	2010	Inherited genetic susceptibility to monoclonal B-cell lymphocytosis.	17
20062064	2010	Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk.	114
20468071	2010	Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts.	22
20855867	2010	Inherited genetic susceptibility to monoclonal B-cell lymphocytosis.	17
12771149	2003	Src kinase regulates the activation of a novel FGD-1-related Cdc42 guanine nucleotide exchange factor in the signaling pathway from the endothelin A receptor to JNK.	28
12771149	2003	Src kinase regulates the activation of a novel FGD-1-related Cdc42 guanine nucleotide exchange factor in the signaling pathway from the endothelin A receptor to JNK.	28

Citation

Dessen P

FARP2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63298/farp2-(ferm-arh-rhogef-and-pleckstrin-domain-protein-2)