Identity
HGNC
LOCATION
2q36.1
LOCUSID
ALIAS
FARSLB,FRSB,HSPC173,NEDBLLA,PheHB,PheRS,RILDBC,RILDBC1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10056
MIM: 609690
HGNC: 17800
Ensembl: ENSG00000116120
Variants:
dbSNP: 10056
ClinVar: 10056
TCGA: ENSG00000116120
COSMIC: FARSB
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000116120 | ENST00000281828 | Q9NSD9 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38069034 | 2023 | FARSB Facilitates Hepatocellular Carcinoma Progression by Activating the mTORC1 Signaling Pathway. | 0 |
| 38069034 | 2023 | FARSB Facilitates Hepatocellular Carcinoma Progression by Activating the mTORC1 Signaling Pathway. | 0 |
| 34159625 | 2021 | Contribution of upregulated aminoacyl-tRNA biosynthesis to metabolic dysregulation in gastric cancer. | 22 |
| 34159625 | 2021 | Contribution of upregulated aminoacyl-tRNA biosynthesis to metabolic dysregulation in gastric cancer. | 22 |
| 31355908 | 2019 | FARSA mutations mimic phenylalanyl-tRNA synthetase deficiency caused by FARSB defects. | 15 |
| 31355908 | 2019 | FARSA mutations mimic phenylalanyl-tRNA synthetase deficiency caused by FARSB defects. | 15 |
| 29573043 | 2018 | Compound heterozygosity for loss-of-function FARSB variants in a patient with classic features of recessive aminoacyl-tRNA synthetase-related disease. | 20 |
| 30014610 | 2018 | Homozygosity for FARSB mutation leads to Phe-tRNA synthetase-related disease of growth restriction, brain calcification, and interstitial lung disease. | 16 |
| 29573043 | 2018 | Compound heterozygosity for loss-of-function FARSB variants in a patient with classic features of recessive aminoacyl-tRNA synthetase-related disease. | 20 |
| 30014610 | 2018 | Homozygosity for FARSB mutation leads to Phe-tRNA synthetase-related disease of growth restriction, brain calcification, and interstitial lung disease. | 16 |
| 22137894 | 2012 | Crystal structure of human mitochondrial PheRS complexed with tRNA(Phe) in the active "open" state. | 26 |
| 22137894 | 2012 | Crystal structure of human mitochondrial PheRS complexed with tRNA(Phe) in the active "open" state. | 26 |
| 20223217 | 2010 | Structure of human cytosolic phenylalanyl-tRNA synthetase: evidence for kingdom-specific design of the active sites and tRNA binding patterns. | 32 |
| 20379614 | 2010 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | 78 |
| 20223217 | 2010 | Structure of human cytosolic phenylalanyl-tRNA synthetase: evidence for kingdom-specific design of the active sites and tRNA binding patterns. | 32 |
Citation
Dessen P
FARSB (phenylalanyl-tRNA synthetase subunit beta)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/63300/farsb-(phenylalanyl-trna-synthetase-subunit-beta)
