FBXL8 (F-box and leucine rich repeat protein 8)

2014-11-01  

Identity

HGNC
LOCATION
16q22.1
LOCUSID
ALIAS
FBL8
FUSION GENES

Other Information

Locus ID:

NCBI: 55336
MIM: 609077
HGNC: 17875
Ensembl: ENSG00000135722

Variants:

dbSNP: 55336
ClinVar: 55336
TCGA: ENSG00000135722
COSMIC: FBXL8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135722ENST00000258200Q96CD0
ENSG00000135722ENST00000517382E5RIE9
ENSG00000135722ENST00000518148J3QRE3
ENSG00000135722ENST00000519378E5RH15
ENSG00000135722ENST00000519917Q96CD0
ENSG00000135722ENST00000519945E5RHS9
ENSG00000135722ENST00000521920E5RFX2
ENSG00000135722ENST00000523893E5RIS0

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
368557782023SCF-FBXL8 contributes to liver metastasis and stem-cell-like features in colorectal cancer cells by mediating ubiquitination and degradation of TP53.3
368557782023SCF-FBXL8 contributes to liver metastasis and stem-cell-like features in colorectal cancer cells by mediating ubiquitination and degradation of TP53.3
331228242021Fbxl8 suppresses lymphoma growth and hematopoietic transformation through degradation of cyclin D3.12
331228242021Fbxl8 suppresses lymphoma growth and hematopoietic transformation through degradation of cyclin D3.12
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105

Citation

Dessen P

FBXL8 (F-box and leucine rich repeat protein 8)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63320/fbxl8-(f-box-and-leucine-rich-repeat-protein-8)