Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 23014
MIM: 609095
HGNC: 13592
Ensembl: ENSG00000135108
Variants:
dbSNP: 23014
ClinVar: 23014
TCGA: ENSG00000135108
COSMIC: FBXO21
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443560 | Breast Neoplasms | Disease | VariantAnnotation | not associated | PD | 29938344 | |
| PA449165 | cyclophosphamide | Chemical | VariantAnnotation | not associated | PD | 29938344 | |
| PA449412 | doxorubicin | Chemical | VariantAnnotation | not associated | PD | 29938344 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37689825 | 2023 | FBXO21 mediated degradation of p85α regulates proliferation and survival of acute myeloid leukemia. | 0 |
| 37689825 | 2023 | FBXO21 mediated degradation of p85α regulates proliferation and survival of acute myeloid leukemia. | 0 |
| 36278814 | 2022 | circRNA-MSR regulates the expression of FBXO21 to inhibit chondrocyte autophagy by targeting miR-761 in osteoarthritis. | 3 |
| 36278814 | 2022 | circRNA-MSR regulates the expression of FBXO21 to inhibit chondrocyte autophagy by targeting miR-761 in osteoarthritis. | 3 |
| 33450132 | 2021 | JUNB-FBXO21-ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy. | 26 |
| 33450132 | 2021 | JUNB-FBXO21-ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy. | 26 |
| 26085330 | 2015 | FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1. | 6 |
| 26299618 | 2015 | CD44 promotes multi-drug resistance by protecting P-glycoprotein from FBXO21-mediated ubiquitination. | 27 |
| 26631746 | 2015 | Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21. | 10 |
| 26085330 | 2015 | FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1. | 6 |
| 26299618 | 2015 | CD44 promotes multi-drug resistance by protecting P-glycoprotein from FBXO21-mediated ubiquitination. | 27 |
| 26631746 | 2015 | Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21. | 10 |
Citation
Dessen P
FBXO21 (F-box protein 21)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/63325/fbxo21-(f-box-protein-21)
