FBXO27 (F-box protein 27)

2014-11-01  

Identity

HGNC
FBXO27
LOCATION
19q13.2
LOCUSID
126433
ALIAS
FBG5,Fbx27
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 126433
MIM: 609099
HGNC: 18753
Ensembl: ENSG00000161243

Variants:

dbSNP: 126433
ClinVar: 126433
TCGA: ENSG00000161243
COSMIC: FBXO27

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000161243ENST00000292853Q8NI29
ENSG00000161243ENST00000292853A0A384MR61
ENSG00000161243ENST00000509137Q8NI29
ENSG00000161243ENST00000509137A0A384MR61
ENSG00000161243ENST00000593847M0R1C3
ENSG00000161243ENST00000598394M0R0I8
ENSG00000161243ENST00000600828M0QYQ6

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil

References

Pubmed IDYearTitleCitations
287437552017Ubiquitination of exposed glycoproteins by SCF(FBXO27) directs damaged lysosomes for autophagy.57
287437552017Ubiquitination of exposed glycoproteins by SCF(FBXO27) directs damaged lysosomes for autophagy.57

Citation

Dessen P

FBXO27 (F-box protein 27)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63329/fbxo27-(f-box-protein-27)