FBXW10 (F-box and WD repeat domain containing 10)

2014-11-01  

Identity

HGNC
FBXW10
LOCATION
17p11.2
LOCUSID
10517
ALIAS
Fbw10,HREP,SM25H2,SM2SH2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10517
MIM: 611679
HGNC: 1211
Ensembl: ENSG00000171931

Variants:

dbSNP: 10517
ClinVar: 10517
TCGA: ENSG00000171931
COSMIC: FBXW10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171931ENST00000301938Q5XX13
ENSG00000171931ENST00000308799Q5XX13
ENSG00000171931ENST00000395665Q5XX13
ENSG00000171931ENST00000574478J3QLH9

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Association of TriC/CCT with target proteins during biosynthesisREACTOMER-HSA-390471
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

References

Pubmed IDYearTitleCitations
369904242023The E3 ubiquitin ligase SCF (FBXW10)-mediated LATS2 degradation regulates angiogenesis and liver metastasis in colorectal cancer.0
377754052023FBXW10: a male-biased E3 ligase in liver cancer.0
369904242023The E3 ubiquitin ligase SCF (FBXW10)-mediated LATS2 degradation regulates angiogenesis and liver metastasis in colorectal cancer.0
377754052023FBXW10: a male-biased E3 ligase in liver cancer.0
314007582020FBXW10 promotes hepatocarcinogenesis in male patients and mice.6
314007582020FBXW10 promotes hepatocarcinogenesis in male patients and mice.6
238995202013FBXW10 is negatively regulated in transcription and expression level by protein O-GlcNAcylation.5
238995202013FBXW10 is negatively regulated in transcription and expression level by protein O-GlcNAcylation.5
204987032010Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10.16
204987032010Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10.16

Citation

Dessen P

FBXW10 (F-box and WD repeat domain containing 10)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63338/fbxw10-(f-box-and-wd-repeat-domain-containing-10)