FDX1 (ferredoxin 1)

2014-11-01  

Identity

HGNC
LOCATION
11q22.3
LOCUSID
ALIAS
ADX,FDX,LOH11CR1D

Other Information

Locus ID:

NCBI: 2230
MIM: 103260
HGNC: 3638
Ensembl: ENSG00000137714

Variants:

dbSNP: 2230
ClinVar: 2230
TCGA: ENSG00000137714
COSMIC: FDX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137714ENST00000260270P10109

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Diseases of metabolismREACTOMER-HSA-5668914
Metabolic disorders of biological oxidation enzymesREACTOMER-HSA-5579029
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)REACTOMER-HSA-5579026
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Metabolism of steroid hormonesREACTOMER-HSA-196071
Pregnenolone biosynthesisREACTOMER-HSA-196108
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cytochrome P450 - arranged by substrate typeREACTOMER-HSA-211897
Endogenous sterolsREACTOMER-HSA-211976
Mitochondrial iron-sulfur cluster biogenesisREACTOMER-HSA-1362409
Electron transport from NADPH to FerredoxinREACTOMER-HSA-2395516

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
388029002024Ferredoxin 1: a gatekeeper in halting lung adenocarcinoma progression through activation of the GPRIN2 signaling pathway.0
388029002024Ferredoxin 1: a gatekeeper in halting lung adenocarcinoma progression through activation of the GPRIN2 signaling pathway.0
361734622023High expression of cuproptosis-related gene FDX1 in relation to good prognosis and immune cells infiltration in colon adenocarcinoma (COAD).19
362807952023Functional spectrum and specificity of mitochondrial ferredoxins FDX1 and FDX2.17
367526382023Ferredoxin 1 regulates granulosa cell apoptosis and autophagy in polycystic ovary syndrome.4
367666922023Copper Death Inducer, FDX1, as a Prognostic Biomarker Reshaping Tumor Immunity in Clear Cell Renal Cell Carcinoma.4
371445192023Expression of Ferredoxin1 in cisplatin‑resistant ovarian cancer cells confers their resistance against ferroptosis induced by cisplatin.2
371937862023Prognostic and immunological role of FDX1 in pan-cancer: an in-silico analysis.0
374300222023Integrated analyses reveal the prognostic, immunological features and mechanisms of cuproptosis critical mediator gene FDX1 in KIRC.1
374536612023FDX1 regulates cellular protein lipoylation through direct binding to LIAS.12
374812092023Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells.6
377342202023Interactions of human mitochondrial Ferredoxin 1 (Adrenodoxin) by NMR; modulation by cytochrome P450 substrate and by truncation of the C-terminal tail.0
381149592023Systematic analysis based on the cuproptosis-related genes identifies ferredoxin 1 as an immune regulator and therapeutic target for glioblastoma.2
381261122023METTL3 promotes non-small-cell lung cancer growth and metastasis by inhibiting FDX1 through copper death-associated pri-miR-21-5p maturation.2
361734622023High expression of cuproptosis-related gene FDX1 in relation to good prognosis and immune cells infiltration in colon adenocarcinoma (COAD).19

Citation

Dessen P

FDX1 (ferredoxin 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63352/fdx1-(ferredoxin-1)