FICD (FIC domain protein adenylyltransferase)

2014-11-01  

Identity

HGNC
LOCATION
12q23.3
LOCUSID
ALIAS
HIP13,HYPE,UNQ3041

Other Information

Locus ID:

NCBI: 11153
HGNC: 18416
Ensembl: ENSG00000198855

Variants:

dbSNP: 11153
ClinVar: 11153
TCGA: ENSG00000198855
COSMIC: FICD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198855ENST00000361549J3KP49
ENSG00000198855ENST00000549641H0YIR6
ENSG00000198855ENST00000552695Q9BVA6
ENSG00000198855ENST00000552695A0A024RBM8
ENSG00000198855ENST00000552758F8VZ74

Expression (GTEx)

0
5
10
15
20

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
338932882021Specificity of AMPylation of the human chaperone BiP is mediated by TPR motifs of FICD.10
342098032021Investigation of the Detailed AMPylated Reaction Mechanism for the Huntingtin Yeast-Interacting Protein E Enzyme HYPE.1
344081542021Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD.9
338932882021Specificity of AMPylation of the human chaperone BiP is mediated by TPR motifs of FICD.10
342098032021Investigation of the Detailed AMPylated Reaction Mechanism for the Huntingtin Yeast-Interacting Protein E Enzyme HYPE.1
344081542021Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD.9
319806312020FICD activity and AMPylation remodelling modulate human neurogenesis.27
329925262020A Fluorescence Polarization-Based High-Throughput Screen to Identify the First Small-Molecule Modulators of the Human Adenylyltransferase HYPE/FICD.4
319806312020FICD activity and AMPylation remodelling modulate human neurogenesis.27
329925262020A Fluorescence Polarization-Based High-Throughput Screen to Identify the First Small-Molecule Modulators of the Human Adenylyltransferase HYPE/FICD.4
279185432017FICD acts bifunctionally to AMPylate and de-AMPylate the endoplasmic reticulum chaperone BiP.53
279185432017FICD acts bifunctionally to AMPylate and de-AMPylate the endoplasmic reticulum chaperone BiP.53
266042612016Global Profiling of Huntingtin-associated protein E (HYPE)-Mediated AMPylation through a Chemical Proteomic Approach.30
266042612016Global Profiling of Huntingtin-associated protein E (HYPE)-Mediated AMPylation through a Chemical Proteomic Approach.30
256010832015A novel link between Fic (filamentation induced by cAMP)-mediated adenylylation/AMPylation and the unfolded protein response.60

Citation

Dessen P

FICD (FIC domain protein adenylyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63383/ficd-(fic-domain-protein-adenylyltransferase)