Identity
HGNC
LOCATION
20q13.12
LOCUSID
ALIAS
C20orf142,Fit2,SIDDIS,dJ881L22.2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 128486
MIM: 612029
HGNC: 16135
Ensembl: ENSG00000197296
Variants:
dbSNP: 128486
ClinVar: 128486
TCGA: ENSG00000197296
COSMIC: FITM2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000197296 | ENST00000396825 | Q8N6M3 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Metabolism | REACTOME | R-HSA-1430728 |
| Metabolism of lipids and lipoproteins | REACTOME | R-HSA-556833 |
| Lipid digestion, mobilization, and transport | REACTOME | R-HSA-73923 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33861319 | 2021 | FIT2 organizes lipid droplet biogenesis with ER tubule-forming proteins and septins. | 18 |
| 34672358 | 2021 | High FITM2 expression promotes cell migration ability of hepatocellular carcinoma by regulating the formation of caveolae and indicates poor patient survival. | 6 |
| 33861319 | 2021 | FIT2 organizes lipid droplet biogenesis with ER tubule-forming proteins and septins. | 18 |
| 34672358 | 2021 | High FITM2 expression promotes cell migration ability of hepatocellular carcinoma by regulating the formation of caveolae and indicates poor patient survival. | 6 |
| 32915949 | 2020 | FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis. | 18 |
| 32915949 | 2020 | FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis. | 18 |
| 30020828 | 2019 | Fat storage-inducing transmembrane protein 2 (FIT2) is less abundant in type 2 diabetes, and regulates triglyceride accumulation and insulin sensitivity in adipocytes. | 7 |
| 30020828 | 2019 | Fat storage-inducing transmembrane protein 2 (FIT2) is less abundant in type 2 diabetes, and regulates triglyceride accumulation and insulin sensitivity in adipocytes. | 7 |
| 28067622 | 2017 | A homozygous FITM2 mutation causes a deafness-dystonia syndrome with motor regression and signs of ichthyosis and sensory neuropathy. | 13 |
| 28067622 | 2017 | A homozygous FITM2 mutation causes a deafness-dystonia syndrome with motor regression and signs of ichthyosis and sensory neuropathy. | 13 |
| 20877624 | 2010 | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. | 20 |
| 20877624 | 2010 | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. | 20 |
Citation
Dessen P
FITM2 (fat storage inducing transmembrane protein 2)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/63389/fitm2-(fat-storage-inducing-transmembrane-protein-2)
