Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 388698
MIM: 616284
HGNC: 33276
Ensembl: ENSG00000143520
Variants:
dbSNP: 388698
ClinVar: 388698
TCGA: ENSG00000143520
COSMIC: FLG2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000143520 | ENST00000388718 | Q5D862 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Immune System | REACTOME | R-HSA-168256 |
| Innate Immune System | REACTOME | R-HSA-168249 |
| Neutrophil degranulation | REACTOME | R-HSA-6798695 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36930145 | 2023 | Scleral Proteome in Noninfectious Scleritis Unravels Upregulation of Filaggrin-2 and Signs of Neovascularization. | 1 |
| 36930145 | 2023 | Scleral Proteome in Noninfectious Scleritis Unravels Upregulation of Filaggrin-2 and Signs of Neovascularization. | 1 |
| 34543471 | 2022 | Dystrophic epidermolysis bullosa pruriginosa: a new case series of a rare phenotype unveils skewed Th2 immunity. | 6 |
| 34984527 | 2022 | Uncommon variants in FLG2 and TCHHL1 are associated with remission of atopic dermatitis in a large longitudinal US cohort. | 4 |
| 34543471 | 2022 | Dystrophic epidermolysis bullosa pruriginosa: a new case series of a rare phenotype unveils skewed Th2 immunity. | 6 |
| 34984527 | 2022 | Uncommon variants in FLG2 and TCHHL1 are associated with remission of atopic dermatitis in a large longitudinal US cohort. | 4 |
| 32437351 | 2020 | Filaggrin and filaggrin 2 processing are linked together through skin aspartic acid protease activation. | 6 |
| 32437351 | 2020 | Filaggrin and filaggrin 2 processing are linked together through skin aspartic acid protease activation. | 6 |
| 30528829 | 2019 | The Amino-Terminal Part of Human FLG2 Is a Component of Cornified Envelopes. | 12 |
| 31079484 | 2019 | Whole-exome sequencing indicates FLG2 variant associated with leg ulcers in Brazilian sickle cell anemia patients. | 3 |
| 30528829 | 2019 | The Amino-Terminal Part of Human FLG2 Is a Component of Cornified Envelopes. | 12 |
| 31079484 | 2019 | Whole-exome sequencing indicates FLG2 variant associated with leg ulcers in Brazilian sickle cell anemia patients. | 3 |
| 29758285 | 2018 | Filaggrin 2 Deficiency Results in Abnormal Cell-Cell Adhesion in the Cornified Cell Layers and Causes Peeling Skin Syndrome Type A. | 20 |
| 30419833 | 2018 | Soluble fibrinogen-like protein 2 levels in patients with hepatitis B virus-related liver diseases. | 8 |
| 29758285 | 2018 | Filaggrin 2 Deficiency Results in Abnormal Cell-Cell Adhesion in the Cornified Cell Layers and Causes Peeling Skin Syndrome Type A. | 20 |
Citation
Dessen P
FLG2 (filaggrin family member 2)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/63409/flg2-(filaggrin-family-member-2)
