FMO2 (flavin containing dimethylaniline monoxygenase 2)

2014-11-01  

Identity

HGNC
LOCATION
1q24.3
LOCUSID
ALIAS
FMO1B1
FUSION GENES

Other Information

Locus ID:

NCBI: 2327
MIM: 603955
HGNC: 3770
Ensembl: ENSG00000094963

Variants:

dbSNP: 2327
ClinVar: 2327
TCGA: ENSG00000094963
COSMIC: FMO2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000094963ENST00000209929Q99518
ENSG00000094963ENST00000483192A0A0D9SG76
ENSG00000094963ENST00000529935A0A0D9SFZ0

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Drug metabolism - cytochrome P450KEGGko00982
Drug metabolism - cytochrome P450KEGGhsa00982
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
FMO oxidises nucleophilesREACTOMER-HSA-217271

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
378005982023Flavin containing monooxygenase 2 regulates renal tubular cell fibrosis and paracrine secretion via SMURF2 in AKI‑CKD transformation.1
379638352023Discovery and identification of the prognostic significance and potential mechanism of FMO2 in breast cancer.0
378005982023Flavin containing monooxygenase 2 regulates renal tubular cell fibrosis and paracrine secretion via SMURF2 in AKI‑CKD transformation.1
379638352023Discovery and identification of the prognostic significance and potential mechanism of FMO2 in breast cancer.0
361140292022Cancer-associated fibroblasts-derived FMO2 as a biomarker of macrophage infiltration and prognosis in epithelial ovarian cancer.5
361140292022Cancer-associated fibroblasts-derived FMO2 as a biomarker of macrophage infiltration and prognosis in epithelial ovarian cancer.5
303814412019Nicotine-N'-Oxidation by Flavin Monooxygenase Enzymes.12
303814412019Nicotine-N'-Oxidation by Flavin Monooxygenase Enzymes.12
289815372017An ancestral human genetic variant linked to an ancient disease: A novel association of FMO2 polymorphisms with tuberculosis (TB) in Ethiopian populations provides new insight into the differential ethno-geographic distribution of FMO2*1.2
289815372017An ancestral human genetic variant linked to an ancient disease: A novel association of FMO2 polymorphisms with tuberculosis (TB) in Ethiopian populations provides new insight into the differential ethno-geographic distribution of FMO2*1.2
201730832010Genetic variation in metabolizing enzyme and transporter genes: comprehensive assessment in 3 major East Asian subpopulations with comparison to Caucasians and Africans.65
205297632010Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE.8
201730832010Genetic variation in metabolizing enzyme and transporter genes: comprehensive assessment in 3 major East Asian subpopulations with comparison to Caucasians and Africans.65
205297632010Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE.8
194201332009Characterization of sulfoxygenation and structural implications of human flavin-containing monooxygenase isoform 2 (FMO2.1) variants S195L and N413K.3

Citation

Dessen P

FMO2 (flavin containing dimethylaniline monoxygenase 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63545/fmo2-(flavin-containing-dimethylaniline-monoxygenase-2)