FXYD1 (FXYD domain containing ion transport regulator 1)

2014-11-01  

Identity

HGNC
LOCATION
19q13.12
LOCUSID
ALIAS
PLM

Other Information

Locus ID:

NCBI: 5348
MIM: 602359
HGNC: 4025
Ensembl: ENSG00000266964

Variants:

dbSNP: 5348
ClinVar: 5348
TCGA: ENSG00000266964
COSMIC: FXYD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000266964ENST00000351325O00168
ENSG00000266964ENST00000455515O00168
ENSG00000266964ENST00000588081O00168
ENSG00000266964ENST00000588607O00168
ENSG00000266964ENST00000588715O00168
ENSG00000266964ENST00000589121K7EQG4
ENSG00000266964ENST00000589209O00168
ENSG00000266964ENST00000612146O00168

Expression (GTEx)

0
100
200
300
400
500
600

Pathways

PathwaySourceExternal ID
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Muscle contractionREACTOMER-HSA-397014
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Ion transport by P-type ATPasesREACTOMER-HSA-936837
Cardiac conductionREACTOMER-HSA-5576891
Ion homeostasisREACTOMER-HSA-5578775

References

Pubmed IDYearTitleCitations
342704622021Expression mode and prognostic value of FXYD family members in colon cancer.10
342704622021Expression mode and prognostic value of FXYD family members in colon cancer.10
332316122020FXYD protein isoforms differentially modulate human Na/K pump function.12
332316122020FXYD protein isoforms differentially modulate human Na/K pump function.12
293838852018Increased FXYD1 and PGC-1α mRNA after blood flow-restricted running is related to fibre type-specific AMPK signalling and oxidative stress in human muscle.19
293838852018Increased FXYD1 and PGC-1α mRNA after blood flow-restricted running is related to fibre type-specific AMPK signalling and oxidative stress in human muscle.19
264104572016FXYD1 negatively regulates Na(+)/K(+)-ATPase activity in lung alveolar epithelial cells.11
267918272016Intensive training and reduced volume increases muscle FXYD1 expression and phosphorylation at rest and during exercise in athletes.9
264104572016FXYD1 negatively regulates Na(+)/K(+)-ATPase activity in lung alveolar epithelial cells.11
267918272016Intensive training and reduced volume increases muscle FXYD1 expression and phosphorylation at rest and during exercise in athletes.9
264299092015Molecular Mechanisms and Kinetic Effects of FXYD1 and Phosphomimetic Mutants on Purified Human Na,K-ATPase.9
264299092015Molecular Mechanisms and Kinetic Effects of FXYD1 and Phosphomimetic Mutants on Purified Human Na,K-ATPase.9
250513422014G-quadruplex formation of FXYD1 pre-mRNA indicates the possibility of regulating expression of its protein product.3
250513422014G-quadruplex formation of FXYD1 pre-mRNA indicates the possibility of regulating expression of its protein product.3
232248792013Coordinated regulation of cardiac Na(+)/Ca (2+) exchanger and Na (+)-K (+)-ATPase by phospholemman (FXYD1).12

Citation

Dessen P

FXYD1 (FXYD domain containing ion transport regulator 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63633/fxyd1-(fxyd-domain-containing-ion-transport-regulator-1)