GABRR1 (gamma-aminobutyric acid type A receptor subunit rho1)

2014-11-01  

Identity

HGNC
LOCATION
6q15
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 2569
MIM: 137161
HGNC: 4090
Ensembl: ENSG00000146276

Variants:

dbSNP: 2569
ClinVar: 2569
TCGA: ENSG00000146276
COSMIC: GABRR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146276ENST00000369451P24046
ENSG00000146276ENST00000435811P24046
ENSG00000146276ENST00000454853P24046
ENSG00000146276ENST00000457434F8WB88
ENSG00000146276ENST00000611484P24046
ENSG00000146276ENST00000621627P24046

Expression (GTEx)

0
1
2
3

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
GABAergic synapseKEGGko04727
GABAergic synapseKEGGhsa04727
Retrograde endocannabinoid signalingKEGGhsa04723
Retrograde endocannabinoid signalingKEGGko04723
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
Nicotine addictionKEGGhsa05033
Nicotine addictionKEGGko05033
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
GABA receptor activationREACTOMER-HSA-977443
GABA A (rho) receptor activationREACTOMER-HSA-977442
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Ligand-gated ion channel transportREACTOMER-HSA-975298

References

Pubmed IDYearTitleCitations
286231692017Mutation of the inhibitory ethanol site in GABA(A) ρ1 receptors promotes tolerance to ethanol-induced motor incoordination.21
286607142017Gene-based interaction analysis shows GABAergic genes interacting with parenting in adolescent depressive symptoms.9
286993262017Gamma-Aminobutyric Acid (Gaba) Receptors Rho (Gabrr) Gene Polymorphisms and Risk for Migraine.6
286231692017Mutation of the inhibitory ethanol site in GABA(A) ρ1 receptors promotes tolerance to ethanol-induced motor incoordination.21
286607142017Gene-based interaction analysis shows GABAergic genes interacting with parenting in adolescent depressive symptoms.9
286993262017Gamma-Aminobutyric Acid (Gaba) Receptors Rho (Gabrr) Gene Polymorphisms and Risk for Migraine.6
272444502016Investigating the Role of Loop C Hydrophilic Residue 'T244' in the Binding Site of ρ1 GABAC Receptors via Site Mutation and Partial Agonism.3
272444502016Investigating the Role of Loop C Hydrophilic Residue 'T244' in the Binding Site of ρ1 GABAC Receptors via Site Mutation and Partial Agonism.3
263218682015GABAAα1 and GABAAρ1 subunits are expressed in cultured human RPE cells and GABAA receptor agents modify the intracellular calcium concentration.4
263218682015GABAAα1 and GABAAρ1 subunits are expressed in cultured human RPE cells and GABAA receptor agents modify the intracellular calcium concentration.4
237558492013Γ-aminobutyric acid(C) (GABAC) selective antagonists derived from the bioisosteric modification of 4-aminocyclopent-1-enecarboxylic acid: amides and hydroxamates.5
237558492013Γ-aminobutyric acid(C) (GABAC) selective antagonists derived from the bioisosteric modification of 4-aminocyclopent-1-enecarboxylic acid: amides and hydroxamates.5
221690952012Rare copy number variants in tourette syndrome disrupt genes in histaminergic pathways and overlap with autism.86
227478842012Nitric oxide potentiation of the homomeric ρ1 GABA(C) receptor function.4
221690952012Rare copy number variants in tourette syndrome disrupt genes in histaminergic pathways and overlap with autism.86

Citation

Dessen P

GABRR1 (gamma-aminobutyric acid type A receptor subunit rho1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63657/gabrr1-(gamma-aminobutyric-acid-type-a-receptor-subunit-rho1)