GALK1 (galactokinase 1)

2014-11-01  

Identity

HGNC
LOCATION
17q25.1
LOCUSID
ALIAS
GALK,GK1,HEL-S-19
FUSION GENES

Other Information

Locus ID:

NCBI: 2584
MIM: 604313
HGNC: 4118
Ensembl: ENSG00000108479

Variants:

dbSNP: 2584
ClinVar: 2584
TCGA: ENSG00000108479
COSMIC: GALK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108479ENST00000225614P51570
ENSG00000108479ENST00000225614V9HWE7
ENSG00000108479ENST00000586244K7ERJ9
ENSG00000108479ENST00000587707K7ERN9
ENSG00000108479ENST00000588479P51570
ENSG00000108479ENST00000588479V9HWE7
ENSG00000108479ENST00000592997K7EII7

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Galactose metabolismKEGGko00052
Amino sugar and nucleotide sugar metabolismKEGGko00520
Galactose metabolismKEGGhsa00052
Amino sugar and nucleotide sugar metabolismKEGGhsa00520
Metabolic pathwaysKEGGhsa01100
Nucleotide sugar biosynthesis, galactose => UDP-galactoseKEGGhsa_M00554
Nucleotide sugar biosynthesis, galactose => UDP-galactoseKEGGM00554
Galactose degradation, Leloir pathway, galactose => alpha-D-glucose-1PKEGGhsa_M00632
Galactose degradation, Leloir pathway, galactose => alpha-D-glucose-1PKEGGM00632
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Galactose catabolismREACTOMER-HSA-70370

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
378343862023Proteomics Profiling of Bladder Cancer Tissues from Early to Advanced Stages Reveals NNMT and GALK1 as Biomarkers for Early Detection and Prognosis of BCa.1
378343862023Proteomics Profiling of Bladder Cancer Tissues from Early to Advanced Stages Reveals NNMT and GALK1 as Biomarkers for Early Detection and Prognosis of BCa.1
328079722021Galactokinase deficiency: lessons from the GalNet registry.10
328079722021Galactokinase deficiency: lessons from the GalNet registry.10
295056882018Improving the Activity and Stability of Human Galactokinase for Therapeutic and Biotechnological Applications.2
298934262018Structural analysis of missense mutations in galactokinase 1 (GALK1) leading to galactosemia type-2.12
302533382018Modulation of the mobility of a key region in human galactokinase: Impacts on catalysis and stability.0
295056882018Improving the Activity and Stability of Human Galactokinase for Therapeutic and Biotechnological Applications.2
298934262018Structural analysis of missense mutations in galactokinase 1 (GALK1) leading to galactosemia type-2.12
302533382018Modulation of the mobility of a key region in human galactokinase: Impacts on catalysis and stability.0
286727482017Clinical evaluation and mutational analysis of GALK and GALE genes in patients with galactosemia in Greece: one novel mutation and two rare cases.1
286727482017Clinical evaluation and mutational analysis of GALK and GALE genes in patients with galactosemia in Greece: one novel mutation and two rare cases.1
242113222014Homozygosity mapping identifies a GALK1 mutation as the cause of autosomal recessive congenital cataracts in 4 adult siblings.4
242113222014Homozygosity mapping identifies a GALK1 mutation as the cause of autosomal recessive congenital cataracts in 4 adult siblings.4
235177312013Static and dynamic interactions between GALK enzyme and known inhibitors: guidelines to design new drugs for galactosemic patients.7

Citation

Dessen P

GALK1 (galactokinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63679/galk1-(galactokinase-1)