Identity
HGNC
LOCATION
5q13.3
LOCUSID
ALIAS
EF-G2mt,EFG2,MRRF2,MST027,MSTP027,RRF,RRF2,RRF2mt,hEFG2,mEF-G 2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 84340
MIM: 606544
HGNC: 29682
Ensembl: ENSG00000164347
Variants:
dbSNP: 84340
ClinVar: 84340
TCGA: ENSG00000164347
COSMIC: GFM2
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Organelle biogenesis and maintenance | REACTOME | R-HSA-1852241 |
| Mitochondrial translation | REACTOME | R-HSA-5368287 |
| Mitochondrial translation termination | REACTOME | R-HSA-5419276 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 26016410 | 2015 | Compound heterozygous GFM2 mutations with Leigh syndrome complicated by arthrogryposis multiplex congenita. | 8 |
| 26016410 | 2015 | Compound heterozygous GFM2 mutations with Leigh syndrome complicated by arthrogryposis multiplex congenita. | 8 |
| 22719265 | 2012 | Polymorphisms in the mitochondrial ribosome recycling factor EF-G2mt/MEF2 compromise cell respiratory function and increase atorvastatin toxicity. | 2 |
| 22719265 | 2012 | Polymorphisms in the mitochondrial ribosome recycling factor EF-G2mt/MEF2 compromise cell respiratory function and increase atorvastatin toxicity. | 2 |
| 20877624 | 2010 | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. | 20 |
| 20877624 | 2010 | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. | 20 |
| 19716793 | 2009 | EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis. | 48 |
| 19716793 | 2009 | EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis. | 48 |
| 18753147 | 2008 | The A3243G tRNALeu(UUR) MELAS mutation causes amino acid misincorporation and a combined respiratory chain assembly defect partially suppressed by overexpression of EFTu and EFG2. | 66 |
| 18753147 | 2008 | The A3243G tRNALeu(UUR) MELAS mutation causes amino acid misincorporation and a combined respiratory chain assembly defect partially suppressed by overexpression of EFTu and EFG2. | 66 |
Citation
Dessen P
GFM2 (GTP dependent ribosome recycling factor mitochondrial 2)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/63755/new-content/tumors-explorer/
