GGA1 (golgi associated, gamma adaptin ear containing, ARF binding protein 1)

2014-11-01  

Identity

HGNC
LOCATION
22q13.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 26088
MIM: 606004
HGNC: 17842
Ensembl: ENSG00000100083

Variants:

dbSNP: 26088
ClinVar: 26088
TCGA: ENSG00000100083
COSMIC: GGA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100083ENST00000325180Q9UJY5
ENSG00000100083ENST00000326597B0QYS0
ENSG00000100083ENST00000343632Q9UJY5
ENSG00000100083ENST00000381756Q9UJY5
ENSG00000100083ENST00000405147B0QYR5
ENSG00000100083ENST00000406772Q9UJY5
ENSG00000100083ENST00000411501B0QYS1
ENSG00000100083ENST00000413251B0QYS5
ENSG00000100083ENST00000423024B0QYS5
ENSG00000100083ENST00000429218B0QYS5
ENSG00000100083ENST00000431745B0QYR8
ENSG00000100083ENST00000439161B0QYS2
ENSG00000100083ENST00000447515B0QYR9
ENSG00000100083ENST00000449944B0QYR6
ENSG00000100083ENST00000453208B0QYS3

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
LysosomeKEGGko04142
LysosomeKEGGhsa04142
Metabolism of proteinsREACTOMER-HSA-392499
Amyloid fiber formationREACTOMER-HSA-977225
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
TBC/RABGAPsREACTOMER-HSA-8854214

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
156157122005GGA proteins mediate the recycling pathway of memapsin 2 (BACE).108
174948682007PI4P promotes the recruitment of the GGA adaptor proteins to the trans-Golgi network and regulates their recognition of the ubiquitin sorting signal.66
158860162005GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network.64
118593762002Structural basis for recognition of acidic-cluster dileucine sequence by GGA1.49
154668872004Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy.49
121357642002Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2.47
126798092003Molecular mechanism of membrane recruitment of GGA by ARF in lysosomal protein transport.44
171512872006GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide.35
164072042006Intracellular trafficking and secretion of adiponectin is dependent on GGA-coated vesicles.30
175965112007The trans-Golgi network accessory protein p56 promotes long-range movement of GGA/clathrin-containing transport carriers and lysosomal enzyme sorting.27

Citation

Dessen P

GGA1 (golgi associated, gamma adaptin ear containing, ARF binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63763/gga1-(golgi-associated-gamma-adaptin-ear-containing-arf-binding-protein-1)