GGA3 (golgi associated, gamma adaptin ear containing, ARF binding protein 3)

2014-11-01  

Identity

HGNC
GGA3
LOCATION
17q25.1
LOCUSID
23163
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23163
MIM: 606006
HGNC: 17079
Ensembl: ENSG00000125447

Variants:

dbSNP: 23163
ClinVar: 23163
TCGA: ENSG00000125447
COSMIC: GGA3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125447ENST00000537686Q9NZ52
ENSG00000125447ENST00000538886Q9NZ52
ENSG00000125447ENST00000577435G3V1K5
ENSG00000125447ENST00000578348Q9NZ52
ENSG00000125447ENST00000578773J3QRK7
ENSG00000125447ENST00000579743A0A087WYN2
ENSG00000125447ENST00000580646J3QS87
ENSG00000125447ENST00000580799J3KSG3
ENSG00000125447ENST00000582376J3QRS8
ENSG00000125447ENST00000582486J3KSS7
ENSG00000125447ENST00000582717Q9NZ52
ENSG00000125447ENST00000583282J3KTR5
ENSG00000125447ENST00000584243J3QRP3
ENSG00000125447ENST00000584550J3KS27
ENSG00000125447ENST00000621217B7Z1E9
ENSG00000125447ENST00000621870G3V1K5
ENSG00000125447ENST00000649398Q9NZ52

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
LysosomeKEGGko04142
LysosomeKEGGhsa04142
Metabolism of proteinsREACTOMER-HSA-392499
Amyloid fiber formationREACTOMER-HSA-977225
Signal TransductionREACTOMER-HSA-162582
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Signaling by METREACTOMER-HSA-6806834
MET receptor recyclingREACTOMER-HSA-8875656
TBC/RABGAPsREACTOMER-HSA-8854214

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
371414372023Do PACS1 variants impeding adaptor protein binding predispose to syndromic intellectual disability?0
371414372023Do PACS1 variants impeding adaptor protein binding predispose to syndromic intellectual disability?0
332064552021Inactivation of the three GGA genes in HeLa cells partially compromises lysosomal enzyme sorting.4
332064552021Inactivation of the three GGA genes in HeLa cells partially compromises lysosomal enzyme sorting.4
323340262020GGA3 interacts with L-type prostaglandin D synthase and regulates the recycling and signaling of the DP1 receptor for prostaglandin D(2) in a Rab4-dependent mechanism.0
323340262020GGA3 interacts with L-type prostaglandin D synthase and regulates the recycling and signaling of the DP1 receptor for prostaglandin D(2) in a Rab4-dependent mechanism.0
292734632019Two novel susceptibility loci for type 2 diabetes mellitus identified by longitudinal exome-wide association studies in a Japanese population.5
292734632019Two novel susceptibility loci for type 2 diabetes mellitus identified by longitudinal exome-wide association studies in a Japanese population.5
268113292016GGA3 Interacts with a G Protein-Coupled Receptor and Modulates Its Cell Surface Export.20
269359702016Regulation of Cell Migration and β1 Integrin Trafficking by the Endosomal Adaptor GGA3.15
268113292016GGA3 Interacts with a G Protein-Coupled Receptor and Modulates Its Cell Surface Export.20
269359702016Regulation of Cell Migration and β1 Integrin Trafficking by the Endosomal Adaptor GGA3.15
264468452015GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival.9
264468452015GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival.9
244072852014Clathrin terminal domain-ligand interactions regulate sorting of mannose 6-phosphate receptors mediated by AP-1 and GGA adaptors.11

Citation

Dessen P

GGA3 (golgi associated, gamma adaptin ear containing, ARF binding protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63765/gene-explorer/humanGenome